MedPath

Study of the Absolute Oral Bioavailability of Dapagliflozin in Healthy Subjects

Phase 1
Completed
Conditions
Type 2 Diabetes Mellitus
Interventions
Registration Number
NCT00908271
Lead Sponsor
AstraZeneca
Brief Summary

The purpose of this study is to estimate the absolute oral bioavailability of dapagliflozin.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
Male
Target Recruitment
7
Inclusion Criteria
  • Healthy male subjects (ages 18 to 45) as determined by medical history, physical examination, 12-lead electrocardiogram (ECG), and clinical laboratory evaluations will be eligible to participate in the study
Exclusion Criteria
  • Evidence of organ dysfunction or any clinically significant deviation from normal in physical examination, vital signs, ECG or clinical laboratory determinations
  • Participation in a radiolabeled investigational study drug trial within 12 months prior to admission to the clinical facility
  • Exposure to significant radiation within 12 months prior to admission to the clinical facility

Study & Design

Study Type
INTERVENTIONAL
Study Design
SINGLE_GROUP
Arm && Interventions
GroupInterventionDescription
DapagliflozinDapagliflozinPO and IV
Primary Outcome Measures
NameTimeMethod
Absolute oral bioavailabilityWithin the 3 days after study drug administration
Secondary Outcome Measures
NameTimeMethod
Adverse events (AE)Within the 3 days after study drug administration
Vital signsWithin the 3 days after study drug administration
Clinical safety labsWithin the 3 days after study drug administration
Electrocardiograms (ECGs)Within the 3 days after study drug administration

Trial Locations

Locations (1)

Covance Clinical Research Unit, Inc.

🇺🇸

Madison, Wisconsin, United States

© Copyright 2025. All Rights Reserved by MedPath