JPRN-UMIN000004338
Completed
未知
Safety and efficacy of umbilical cord blood (UCB) transplantation using a low-dose total body irradiation (TBI) containing regimen for hematologic malignancies - Safety and efficacy of umbilical cord blood (UCB) transplantation using a low-dose total body irradiation (TBI) containing regimen for hematologic malignancies
Hematology, Osaka City University, Graduate School of Meicine0 sites7 target enrollmentOctober 6, 2010
Overview
- Phase
- 未知
- Intervention
- Not specified
- Conditions
- Hematologic malignancies with an indication for allogeneic hematopoietic stem cell transplantation
- Sponsor
- Hematology, Osaka City University, Graduate School of Meicine
- Enrollment
- 7
- Status
- Completed
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •(1\)Patients who have any major organ dysfunction as follow (a) Heart: Ejection fraction \<30% at rest (b) Lung: %VC\<30% or FEV1\.0%\<40% or PaO2\<60mmHg(SpO2\<90%) on room air (c) Kidney: serum creatinine level \>2\.0 mg/dl (d) Liver: total bilirubin level \>2\.0 mg/dl or ALT\>3\.0 x ULN (upper limit of normal) or chronic active hepatitis or cirrhosis (2\) Poorly controlled hypertention (3\) Positivity for HIV antibody (4\) Uncontrolled active infections (5\) Uncontrolled central nervous system involvement (6\) Pregnant, nursing or possibly pregnant woman (7\) Patients with mental disorder who are considered difficult to participate in the study (8\) Known hypersensitivity to any of the drugs in the conditioning regimen or drugs used for GVHD prophylaxis (9\) Patients with positive donor\-specific HLA antibodies(DSA) (10\) Engraftment failure after allogeneic hematopoietic stem cell transplantation (11\) Inappropriate to participate in this study as judged by the physician in charge
Outcomes
Primary Outcomes
Not specified
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