Safety and efficacy of umbilical cord blood (UCB) transplantation using a low-dose total body irradiation (TBI) containing regimen for hematologic malignancies - Safety and efficacy of umbilical cord blood (UCB) transplantation using a low-dose total body irradiation (TBI) containing regimen for hematologic malignancies

Hematology, Osaka City University, Graduate School of Meicine0 个研究点目标入组 7 人开始时间: 2010年10月6日最近更新: 2023年10月17日

适应症

试验速览

暂无简介。

•(1)Patients who have any major organ dysfunction as follow (a) Heart: Ejection fraction <30% at rest (b) Lung: %VC<30% or FEV1.0%<40% or PaO2<60mmHg(SpO2<90%) on room air (c) Kidney: serum creatinine level >2.0 mg/dl (d) Liver: total bilirubin level >2.0 mg/dl or ALT>3.0 x ULN (upper limit of normal) or chronic active hepatitis or cirrhosis (2) Poorly controlled hypertention (3) Positivity for HIV antibody (4) Uncontrolled active infections (5) Uncontrolled central nervous system involvement (6) Pregnant, nursing or possibly pregnant woman (7) Patients with mental disorder who are considered difficult to participate in the study (8) Known hypersensitivity to any of the drugs in the conditioning regimen or drugs used for GVHD prophylaxis (9) Patients with positive donor-specific HLA antibodies(DSA) (10) Engraftment failure after allogeneic hematopoietic stem cell transplantation (11) Inappropriate to participate in this study as judged by the physician in charge

发起方

Hematology, Osaka City University, Graduate School of Meicine