Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss

• Conditions: Neutrophil Extracellular Traps; Antiphospholipid Antibody-induced Pregnancy Loss

• Registration Number: NCT03735108
• Lead Sponsor: Shanghai First Maternity and Infant Hospital

Brief Summary

1. Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance;

2. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group;

3. Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group;

4. After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.

Detailed Description

Not available

Study Timeline

• Status Verified: 2018-10
• Study Start: 2018-11-01
• Study First Submitted: 2018-11-01
• Study First Submitted QC: 2018-11-07
• Last Update Submitted: 2018-11-07
• Study First Posted: 2018-11-08
• Last Update Posted: 2018-11-08
• Primary Completion: 2019-06-30
• Study Completion: 2019-06-30

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 100

Inclusion Criteria

• Clinical diagnosis of Recurrent spontaneous abortion
• Clinical diagnosis of Antiphospholipid syndrome

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Exclusion Criteria

• Other autoimmune diseases
• Hematopoietic system diseases
• Cardiovascular system diseases
• Gastrointestinal system diseases
• Urinary system diseases
• Nervous system or mental diseases
• Have taken other drugs recently

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
NETs level	through study completion, an average of 8 months	Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens.

Secondary Outcome Measures

Name	Time	Method
complete blood count (CBC)	through study completion, an average of 8 months	CBC is a blood panel requested by a doctor or other medical professional that gives information about the cells in a patient's blood, such as the cell count for each blood cell type and the concentrations of hemoglobin.

Trial Locations

Locations (1)

Shanghai First Maternity and Infant Hospital; 🇨🇳 Shanghai, China