NCT03735108Unknown不适用
Neutrophil Extracellular Traps Mediate Antiphospholipid Antibody-induced Pregnancy Loss
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- NETs level
研究概览
简要总结
- Establish a multi-platform detection system for neutrophil extracellular traps in blood and tissues, and evaluate the detection performance;
- Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of patients with antiphospholipid antibody-induced pregnancy loss and normal control group;
- Comparing the expression levels of neutrophil extracellular traps in peripheral blood and decidua of mice with antiphospholipid antibody-induced pregnancy loss and normal control group;
- After treatment of antiphospholipid antibody-induced mouse abortion model with metformin,the effect of metformin on embryo loss rate and viable embryo body weight was observed.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 25 Years 至 41 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of Recurrent spontaneous abortion
- •Clinical diagnosis of Antiphospholipid syndrome
排除标准
- •Other autoimmune diseases
- •Hematopoietic system diseases
- •Cardiovascular system diseases
- •Gastrointestinal system diseases
- •Urinary system diseases
- •Nervous system or mental diseases
- •Have taken other drugs recently
结局指标
主要结局
NETs level
时间窗: through study completion, an average of 8 months
Neutrophil extracellular traps (NETs) are networks of extracellular fibers, primarily composed of DNA from neutrophils, which bind pathogens.
次要结局
- complete blood count (CBC)(through study completion, an average of 8 months)
研究者
Shihua Bao
Associate Professor
Shanghai First Maternity and Infant Hospital
研究点 (1)
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