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Clinical Trials/NL-OMON40345
NL-OMON40345CompletedNot Applicable

The role of neutrophil extracellular trap formation in sickle cell disease - NET, in-vitro experiments

Academisch Medisch Centrum0 sites30 target enrollmentStarted: TBDLast updated:
Conditions

Trial Snapshot

Phase
Not Applicable
Status
Completed
Enrollment
30

Study Overview

Brief Summary

No summary available.

Study Design

Study Type
Observational

Eligibility Criteria

Ages
18 to 99 (—)

Inclusion Criteria

  • For patients:
  • 1. High performance liquid chromatography confirmed diagnosis of HbSS, HbSC, HbS*0- or HbS*+-thalassemia genotype in SCD patients. 2. Written informed consent by the patient. 3.18 years and older
  • For healthy volunteers:
  • 1. Age * 18 years; 2. WHO performance score 0; 3. healthy race-matched family member or acquaintance

Exclusion Criteria

  • For patients
  • 1. HbSC or HbS*+- thalassemia genotype . 2. Pregnancy 3. Active cancer 4. Chronic HIV infection 5. Recent vaso-occlusive crisis (< 1 months) 6. Chronic transfusion therapy 7. Recent blood transfusion (< 3 months)
  • For healthy volunteers:
  • Carrier of sickle cell gene or other hemoglobinopathy

Investigators

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