NL-OMON40345CompletedNot Applicable
The role of neutrophil extracellular trap formation in sickle cell disease - NET, in-vitro experiments
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Academisch Medisch Centrum
- Enrollment
- 30
Study Overview
Brief Summary
No summary available.
Study Design
- Study Type
- Observational
Eligibility Criteria
- Ages
- 18 to 99 (—)
Inclusion Criteria
- •For patients:
- •1. High performance liquid chromatography confirmed diagnosis of HbSS, HbSC, HbS*0- or HbS*+-thalassemia genotype in SCD patients. 2. Written informed consent by the patient. 3.18 years and older
- •For healthy volunteers:
- •1. Age * 18 years; 2. WHO performance score 0; 3. healthy race-matched family member or acquaintance
Exclusion Criteria
- •For patients
- •1. HbSC or HbS*+- thalassemia genotype . 2. Pregnancy 3. Active cancer 4. Chronic HIV infection 5. Recent vaso-occlusive crisis (< 1 months) 6. Chronic transfusion therapy 7. Recent blood transfusion (< 3 months)
- •For healthy volunteers:
- •Carrier of sickle cell gene or other hemoglobinopathy
Investigators
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