Polymorphisms of Interleukins, Glypican, and Human Leukocyte Antigen Genes and Treatment Response in Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Relapsing-Remitting
- Registration Number
- NCT02769767
- Lead Sponsor
- Instituto Jalisciense de Cancerologia
- Brief Summary
HLA-DRB1 \* Gene and some genes involved in inflammation and immunity (IL-7R, GPC5, CTSS) have been linked to risk of MS and the response to treatment with immunomodulators. This research aims to estimate the risk that confers some variations in the sequence of these genes.
- Detailed Description
Genes HLA-DRB1 \* and some genes involved in inflammation and immunity have been linked to risk of MS and the response to treatment with immunomodulators.
The HLA-DRB1 \* genes have been associated with risk and response to treatment in MS in multiple studies; however, other genes have been controversial. This research aims to estimate the risk for MS that confers some variations in the sequence of IL-7R, GPC5, CTSS, HLA-DRB1 genes. Furthermore, it seeks to determine whether these gene variants (polymorphisms) are associated with treatment response to immunomodulators.
Subjects with MS and healthy subjects will be taken to assess the risk for MS. Besides the investigators obtain the medical history of relapse to assess response to treatment in accordance with Expanded Disability Status Scale (EDSS) and relapses.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 500
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Treatment response evaluated by relapses per year, evaluated during two years after recruitment. Two Years Treatment response evaluated by relapses per year during two years after recruitment. The relapses are defined by any neurological sign or symptom that happens at least 30 days after any previous neurological deterioration episode began.
Treatment response evaluated by Expanded Disability Status Scale (EDSS) during two years after recruitment. Two Years Treatment response evaluated by Expanded Disability Status Scale (EDSS) during two years after recruitment.
The EDSS scale ranges from 0 to 10; the increments are in 0.5. Scoring is based on an examination by a neurologist about the level of disability.
- Secondary Outcome Measures
Name Time Method Multiple Sclerosis Risk Conferred by Single Nucleotide Polymorphisms (SNPs) of Interleukins, Glypican, and Human Leukocyte Antigen Genes. One Year The risk conferred by SNPs of Interleukins, Glypican, and Human Leukocyte Antigen Genes: calculated by odds ratio when the allele frequencies of SNPs cases are compared with the allele frequencies of SNPs in healthy subjects.
Related Research Topics
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Trial Locations
- Locations (1)
Instituto Jalisciense de Cancerología
🇲🇽Guadalajara, Jalisco, Mexico
Instituto Jalisciense de Cancerología🇲🇽Guadalajara, Jalisco, MexicoJOSE A. CRUZ RAMOS, PhDContact0152 3314886313josealfonsocr@gmail.com