NCT00168207
Completed
Not Applicable
The Relationship of Single Nucleotide Polymorphisms in the Interleukin-7 Receptor-α Gene to CD4+ Immune Recovery in HIV Infected Patients Who Begin Antiretroviral Treatment With HAART
The Alfred1 site in 1 country106 target enrollmentMay 2005
ConditionsHIV Infections
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- HIV Infections
- Sponsor
- The Alfred
- Enrollment
- 106
- Locations
- 1
- Status
- Completed
- Last Updated
- 14 years ago
Overview
Brief Summary
The aim is to investigate the hypothesis that IL7-receptor polymorphisms contribute to the differential immune recovery of CD4 + T cells following HAART
Detailed Description
AIM: To examine the association between the four haplotypes of IL-7Rα gene and a cohort of HIV infected patients who have commenced HAART with varying CD4+ T lymphocyte responses. METHODS: IL-7Rα gene SNPs and haplotypes will be measured by constructing DNA pools, and PCR amplification and DNA sequencing. IL-7Rα expression will be examined using constitutive expression of IL-7Rα, IL-7Rα gene expression, and inducible expression of IL7Rα.
Investigators
Jennifer Hoy
Professor Jennifer Hoy
The Alfred
Eligibility Criteria
Inclusion Criteria
- •Men or women at least 18 years of age
- •First antiretroviral regimen composed of HAART as defined by at least three antiretrovirals
- •Controlled viremia for a period of at least 12 months following commencement of HAART. Controlled viremia is defined as HIV viral load of ≤ 500 copies/mL on bDNA testing (versions 2 and 3) and \<400 copies/ml measured by RT-PCR assay by 6 months treatment.
- •CD4 cell count \<500 at commencement of HAART
- •Measurement of CD4+ cell count on at least 3 time points, in the 12 months post commencement of HAART.
Exclusion Criteria
- •Exclude patients treated for HIV seroconversion illness
- •Exclude patients on immunomodulatory therapy such as IL-2, hydroxyurea or prednisolone or who have received an HIV therapeutic vaccine
Outcomes
Primary Outcomes
Not specified
Study Sites (1)
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