Causal Role of Top-Down Theta Oscillations in Prioritization

Not Applicable

• Conditions: Working Memory; Epilepsy

• Registration Number: NCT06252532
• Lead Sponsor: University of North Carolina, Chapel Hill

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-2-1
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Enrolling by invitation
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Inclusion Criteria:<br><br> - Able to provide informed consent<br><br> - History of medically intractable epilepsy<br><br> - Speak and understand English<br><br> - For the stimulation session, the participant must have electrodes in the relevant<br> locations<br><br>Exclusion Criteria:<br><br> - Current diagnosis of other neurological illnesses including ischemic stroke,<br> intracerebral hemorrhage, brain neoplasm<br><br> - Major systemic illness<br><br> - Severe cognitive impairment - diagnosed by clinician in neuropsychiatric evaluation<br><br> - Severe psychiatric illness<br><br> - Excessive use of alcohol or other substances<br><br> - Anything that, in the opinion of the investigator, would place the participant at<br> increased risk or preclude the participant's full compliance with or completion of<br> the study

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Change in Working Memory Task Performance - Pashler's working memory capacity metric (k);Change in Working Memory Task Performance - Reaction Time;Intracranial EEG Multi-taper fft;Intracranial EEG weighted phase lag index (wPLI)

Secondary Outcome Measures

Name	Time	Method
Intracranial EEG Wavelets;Intracranial EEG phase locking;Intracranial EEG Granger causality