64CuATSM Positron Emission Tomography with Quantitative Susceptibility Mapping Magnetic Resonance Imaging as a Biomarker of Motor Neurone Disease
Not Applicable
- Conditions
- motor neurone diseaseNeurological - Neurodegenerative diseases
- Registration Number
- ACTRN12623000067673
- Lead Sponsor
- Florey Institute of Neuroscience and Mental Health
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot yet recruiting
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
limb onset variant of motor neurone disease / amyotrophic lateral sclerosis
Exclusion Criteria
1) presence of other known neurological or psychiatric diseases which may cause MRI changes
2) history of learning disability / intellectual disability
3) unable to tolerate PET or MRI scanning
4) diagnosis of dementia
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Region of interest 64CuATSM PET signal / control region uptake value in subjects will be compared to region of interest 64CuATSM PET signal / control region uptake value in an existing control group.[This is a cross-sectional study. PET/MRI scans and clinical data will be collected once only on the day of enrollment.]
- Secondary Outcome Measures
Name Time Method MRI quantitative susceptibility mapping (QSM) signal<br>QSM signal will be determined using validated automated methods, e.g. the JHU/KKI QSM Toolbox V3.0.[This is a cross-sectional study. Scanning will take place once only on the on the day of enrolment.]