Assessing Cough Peak Flow (CPF) Using Ventilator built-in Flow-meter to Predict Extubation Success: A Single Centre Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Early extubation success rate (EES rate)
研究概览
简要总结
Successful weaning from mechanical ventilation in ICU patients depends on patient ability to breathe spontaneously and on cough efficiency. Previous studies found that cough peak flow (CPF) at 60 L/min threshold predicted extubation failure. These studies measured CPF using a dedicated flow-meter that required patient disconnection from the ventilator, limiting the generalizability of this procedure. This study aimed to predict extubation outcome in a consecutive series of patients by measuring CPF from the ventilator flow-meter. CPF measurements were done by freezing ventilator screen and scrolling the cursor to the maximal value of CPF during expiration and Tidal Volume (TV) in preceding inspiration.
The objective was to assess the performance of CPF to predict early extubation outcome.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Intubation > 24h
- •Eligible for scheduled weaning trial and then scheduled extubation
- •Mechanical ventilation from Evita XL ventilator (Dräger, Germany)
- •Patient's agreement to participate
排除标准
- •Withdrawal decision of life supporting care
结局指标
主要结局
Early extubation success rate (EES rate)
时间窗: 48 hours
Defining a relation between the CPF/TV ratio before extubation and early extubation success rate
次要结局
- Scheduled weaning trial success rate(48 hours)