Bronchial Hyperreactivity in Children With Crohn Disease
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 47
- 试验地点
- 1
- 主要终点
- Methacholine challenge test
研究概览
简要总结
Background: Latent pulmonary involvement is described in Crohn Disease(CD). Bronchial hyperreactivity measured by the Methacholine Challenge Test (MCT) has been evaluated in two studies involving mainly adults.Our aim was to determine the frequency of bronchial hyperreactivity in pediatric patients followed and treated for Crohn disease.
Methods: Twenty-three children with Crohn disease completed a questionnaire, followed by spirometry, Methacholine Challenge Test (MCT) and determination of Fractional Exhaled NO (FENO). The control group included patients evaluated for functional cough who had negative Methacholine Challenge Test (MCT).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Years 至 25 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children with Crohn disease
- •Children that can perform lung function tests (MCT)
排除标准
- •Upper respiratory tract infection last month
- •Fever or Pneumonia last month
- •Other chronic diseases
- •Other respiratory diseases
结局指标
主要结局
Methacholine challenge test
时间窗: 18 months
As assessed by methacholine challenge test with determination of PC20.
次要结局
- Pediatric Crohn's Disease Activity Index (PCDAI)(Day 1)
- Eosinophils count(Day 1)
- Fractional Exhaled NO(Day 1)