TCTR20201203005尚未招募2 期
Comparing the perioperative blood loss in hypovolemic phlebotomy vs non-hypovolemic phlebotomy with low central venous pressure in patients undergoing open liver resection, A Prospective Randomized Double-Blind Controlled Study
none0 个研究点目标入组 100 人开始时间: 2020年12月3日最近更新:
适应症
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 70 Years（—）
- 性别
- All
入选标准
- •1. All genders, age 18 to 70 years old
- •2. American Society of Anesthesiologists (ASA) physical status classification of I-III
- •3. The patients who scheduled in elective open liver resection and diagnosed Hepatocellular Carcinoma, Cholangiocarcinoma, Liver metastasis, and Benign malignant tumor.
排除标准
- •1. Pregnancy
- •2. Refusal of blood and blood products transfusion
- •3. Anemia (Hb <10 g/dL)
- •4. Active cardiac conditions (unstable coronary syndromes, decompensated heart failure, significant arrhythmias, severe valvular disease, active coronary artery disease within 6 months prior surgery)
- •5. History of significant cerebrovascular disease (Patients with clinically significant stroke/CVA within 6 months prior surgery, severe carotid stenosis)
- •6. History of significant peripheral vascular disease (Patients with regular claudication)
- •7. History of congestive heart failure (CHF)
- •8. Restrictive or obstructive pulmonary disease (COPD)
- •9. Renal dysfunction (creatinine > 1.8 mg/dL)
- •10. Abnormal coagulation parameters (INR >1.5 not on warfarin and/or platelet count <100,000)
- •11. Evidence of hepatic metabolic disorder (bilirubin >2 mg/dL or ALT >75 U/L)
- •12. Preoperative autologous blood donation
- •13. Presence of active infection (Evidence of positive hemoculture)
- •14. Tumor size > 10 cm.
- •Withdrawal criteria:
- •1. Unresectable tumor
- •2. Persistent intraoperative hypotension that cannot be corrected with vasopressors.
- •3. Cardiac arrest during operation
- •4. Low central venous pressure (< 5 mmHg) cannot be achieved before and during parenchymal resection.
- •5. Massive bleeding due to major vascular injury
研究者
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