A clinical trial of Trans-cranial Direct current stimulation in Depressive disorder.
- Conditions
- Health Condition 1: F320- Major depressive disorder, singleepisode, mildHealth Condition 2: F321- Major depressive disorder, singleepisode, moderateHealth Condition 3: F322- Major depressive disorder, singleepisode, severe without psychotic features
- Registration Number
- CTRI/2023/05/052214
- Lead Sponsor
- Armed Forces Medical Research Council
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
Patients with Depressive disorder without psychotic features currently experiencing an acute depressive episode aged between 18-60 years and consenting for the study will be enrolled. Comorbid anxiety symptoms will be permitted.
1.Those diagnosed with Neurodevelopmental disorders, Schizophrenia/ psychotic disorders, BPAD, OCD, Dissociative disorders, Eating disorders, Alcohol and Substance use disorders.
2.Neurological conditions like Movement disorders, Multiple sclerosis, Epilepsy, Cerebrovascular diseases and CNS infections.
3.Those having uncontrolled Diabetes, Hypertension or acute or chronic inflammatory conditions.
4.Those with history of endocrine diseases involving disorders of thyroid gland, parathyroid gland and adrenal gland.
5.Pregnant or lactating patients.
6.Those on anti-inflammatory drugs like NSAIDs and corticosteroids.
7.Those who have received any other form of neurostimulation in last 06 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To study the impact of tDCS on levels of Cytokines, Cortisol and serum ACTH in patients of Depressive disorder. <br/ ><br>Plasma IL-2, IL-4, IL-6, IL-10, IL-17a, Interferon (IFN)-?, TNF-a, basal cortisol and ACTH will be measured.Timepoint: At baseline and after 6 weeks
- Secondary Outcome Measures
Name Time Method To determine the impact of tDCS on symptoms of depression measured by Hamilton Depression Rating Scale (HDRS)Timepoint: At baseline and after 6 weeks