Effects of Nasal-High Flow therapy on nocturnal hypoventialtion and autonomic nervous system function in patients with neuromuscular diseases
Not Applicable
Recruiting
- Conditions
- G12E74Spinal muscular atrophy and related syndromesOther disorders of carbohydrate metabolism
- Registration Number
- DRKS00013905
- Lead Sponsor
- Department für Neurologie - Klinik für Schlafmedizin und neuromuskuläre Erkrankungen Universitätsklinikum Münster
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 30
Inclusion Criteria
a. Age > 18 years (no age limit)
b. able to consent
c. proven NMD
d. ongoing nocturnal NIV therapy with a nasal mask for hypoventilation due to a NMD
e. good tolerance of and adherence to the ongoing NIV therapy with minimal nasal mask-related problems/discomfort
f. no vital indication for NIV use at night
Exclusion Criteria
- Body Mass Index (BMI) > 35
- Heart failure with left ventricular ejection fraction <50%
- Chronic obstructive pulmonary disease, emphysema
- Severe psychiatric disease including dementia
- Thoracic wall disease
- Cardiac pacemaker
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Transcutaneous CO2 [mmHG]<br>-> measured at night and under the above mentioned interventions
- Secondary Outcome Measures
Name Time Method Heart rate [bpm], systolic blood pressure [mmHG], diastolic blood pressure [mmHG], stroke volume index [L/min/m²], high frequency component of diastolic blood pressure variability[%], low frequency component of heart rate variability [%], respiratory rate [/min], tidal volume [ml], minute ventilation [L/min], oxygen saturation [%], high frequency component of heart rate variability [%], low frequency component of diastolic blood pressure variability [%]<br>-> measured at night and under the above mentioned interventions