The role of fat in symptom generation in patients with functional dyspepsia

Completed

Conditions: indigestion
Upper abdominal complaints
10017943

Registration Number: NL-OMON33884

Lead Sponsor: niversitair Medisch Centrum Utrecht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 25

Inclusion Criteria

18-65 years old
Recurrent bothersome postprandial fullness, early satiation and/or epigastric pain
At least 2 days per week for 3 months or more

Exclusion Criteria

Esophagitis
Barrett's esophagus
Peptic ulcer disease
Prior gastrointestinal surgery
Pregnancy
Drug- or alcohol abuse
Use of Aspirin in combination with Clopidogrel

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Differences in duodenal mRNA expression of genes, involved in the<br /><br>chylomicron-apoA-IV-CCK pathway, between FD patients and healthy controls.<br /><br><br /><br>Relationship between duodenal mRNA expression of genes, involved in the<br /><br>chylomicron-apoA-IV-CCK pathway, upon duodenal lipid load and sensitivity to<br /><br>gastric distension and/or gastric emptying rate of FD patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Differences in plasma and duodenal mucosal concentrations of apoA-IV and/or CCK<br /><br>between FD patients and healthy controls.<br /><br><br /><br>Relationship between plasma and duodenal mucosal concentrations of apoA-IV<br /><br>and/or CCK upon duodenal lipid load and sensitivity to gastric distension<br /><br>and/or gastric emptying rate of FD patients.</p><br>