Effects of a high fat, high carbohydrate meal on metabolic endotoxemia and reproductive function in overweight and obese males

Not Applicable

Completed

• Conditions: Metabolic Endotoxemia; Reproductive Function; Gut permeability; overweight/obesity; Diet and Nutrition - Other diet and nutrition disorders; Reproductive Health and Childbirth - Other reproductive health and childbirth disorders; Diet and Nutrition - Obesity

• Registration Number: ACTRN12617001034325
• Lead Sponsor: niversity Of South Australia

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-07-17
• Study Completion: 2018-11-15
• Last Update Posted: 22 July 2019

Recruitment & Eligibility

• Status: Completed
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Males aged between 18-50 with a BMI over 25.

Exclusion Criteria

consumption of fish oil or probiotic supplements.
immune suppressant medication
androgen treatments/hormone therapy
inflammatory disease (IBS/IBD, kidney disease, autoimmune disease)
infectious blood diseases
antibiotic use

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in endotoxin level in blood[Endotoxin was measured at 0,1,2,3,4 hour intervals for all 12 arms];Reproductive Hormone level changes in serum - testosterone[Testosterone was measured at 0,1,2,3,4 hour intervals for all 12 arms]

Secondary Outcome Measures

Name	Time	Method
Dietary history in form of 3 day diet diary (2 weekdays and one weekend day - excluding days participant has been to the clinic for the trial)[Dietary histories were collected at all 12 visits];Sleep Quality - questionnaire (Pittsburgh Sleep Quality Index)[Sleep quality questionnaires were collected at all 12 visits];Physical Activity Questionnaire (Baecke Questionnaire)[Physical activity questionnaires were collected at the additional 12 visits.];Changes in reproductive hormones in serum - follicle stimulating hormone[FSH was measured at 0,1,2,3,4 hour intervals for all 12 arms];Changes in reproductive hormones in serum - estrogen[Estrogen was measured at 0,1,2,3,4 hour intervals for all 12 arms];Changes in reproductive hormones in serum- SHBG[Both visits at time 0,1,2,3,4 hour intervals];Changes in reproductive hormones in serum - lutenising hormone, [LH was measured at 0,1,2,3,4 hour intervals for all 12 arms]