Does short term high fat, high calorie feeding impair blood flow to the muscles in healthy people?
Not Applicable
Completed
- Conditions
- Cardiometabolic outcomesGlucose toleranceMetabolic and Endocrine - DiabetesCardiovascular - Diseases of the vasculature and circulation including the lymphatic system
- Registration Number
- ACTRN12619000869178
- Lead Sponsor
- Deakin University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
•Age 18-45 years
•BMI 18-24.9 Kg/m2.
•Normotensive (seated brachial blood pressure <140/90 mmHg).
•Have given signed informed consent to participate in the study.
•Have no known food allergies.
•Have been weight stable for past 3 months.
Exclusion Criteria
Update
• Not meeting the inclusion criteria outlined above
• Smoking status – regular smoker in the last 10 years and/or >10 years of smoking history
• History of severe liver disease, any vascular or cardiovascular disease or type 2 diabetes
• Pregnancy/lactation
• Family history of type 2 diabetes (i.e. a parent with type 2 diabetes).
• Person on a high fat diet (e.g. keto diet).
• Person on a high saturated fat diet (>18% energy from saturated fat).
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Insulin response during a Mixed Meal Challenge. This involves participants consuming a drink similar to a protein shake and giving blood samples at 0, 15, 30, 60, 90 and 120 mins.[Day 0, Day 4 and Day 8 (primary time point)];Microvascular blood flow using ultrasound technique. This involves infusion of a safe and approved contrast agent and placing an ultrasound probe on area of interest (arm) and imaging.[Day 0, Day 4 and Day 8 (primary time point)]
- Secondary Outcome Measures
Name Time Method Body fat percentage using a DEXA scan[Day 0, Day 4 and Day 8 (primary time point)]