Prognostic Value of Early Oxidative Stress Biomarkers in Patients With Sepsis
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Sepsis, Severe
- Sponsor
- Zhongnan Hospital
- Enrollment
- 120
- Locations
- 1
- Primary Endpoint
- Death of the patients
- Last Updated
- 7 years ago
Overview
Brief Summary
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients.
Detailed Description
Acute kidney injury (AKI) is a common condition among sepsis patients in the intensive care unit (ICU) and is associated with high morbidity and mortality. Oxidative stress biomarkers were investigated in panels and were reported to predict renal failure in sepsis patients. Research on AKI has focused on new damage biomarkers for early detection of AKI and worsening of renal function. Some biomarkers would be able to identify who will recover and not recover better than serum creatinine. Thus, a combining functional and damage markers as well as oxidative stress biomarkers are needed to predict the occurrence or progression of AKI in critically ill patients. Therefore, this prospective, observational study will be conducted in Mainland China
Investigators
ZhiYong Peng
professor
Zhongnan Hospital
Eligibility Criteria
Inclusion Criteria
- •sepsis patients in appropriate age
Exclusion Criteria
- •ever blood transfusion ever CPR（cardiopulmonary resuscitation)
Outcomes
Primary Outcomes
Death of the patients
Time Frame: 2 weeks after admission to ICU
Mortality of the studied patients
presence of AKI
Time Frame: a week after admission to ICU
Use serum creatinine or urine output（The KDIGO Guidelines 2012) to asess whether AKI happens to the studied subjects within a week after admission to ICU
Secondary Outcomes
- Use serum creatinine to assess renal function of the patients(the 1 day when the patients admitted to ICU)