Biochemical Mediators After Implant Loading

Completed

• Conditions: Implant Loading

• Registration Number: NCT03009942
• Lead Sponsor: Gazi University

Brief Summary

This study evaluates the nitric oxide and arginase levels in patients with dental implants. Peri-implant sulcular fluid and saliva samples were collected after loading of the implants

Detailed Description

Nitric oxide (NO) metabolism is associated with the clinical inflammatory state of peri-implant tissues and also affected by the mechanic stimulus. Therefore, The NO content of PISF reflects two different measures and can serve as an indicator of peri-implant soft tissue inflammation and/or bone response to force application and loading Arginase may reduce NO production by depleting the common substrate. Thus, increased salivary arginase activities detected in periodontitis patients may cause decreased NO synthesis and lead to a decrease in the antibacterial property of saliva.

Study Timeline

• Study Start: 2010-01
• Primary Completion: 2011-12
• Study Completion: 2012-12
• Status Verified: 2017-01
• Study First Submitted: 2017-01-02
• Study First Submitted QC: 2017-01-02
• Last Update Submitted: 2017-01-02
• Study First Posted: 2017-01-04
• Last Update Posted: 2017-01-04

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

• Patients with ≥ 20 teeth, no systemic diseases that could affect bone metabolism, no smoking habits, and had one or more implants

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Biochemical parameters (nitric oxide and arginase) in periimplant sulcular fluid and saliva	Baseline and 1, 3 and 6 months after implant loading	The changes in nitric oxide and arginase levels after implant loading were determined.

Secondary Outcome Measures

Name	Time	Method
Plaque index	Baseline and 1, 3 and 6 months after implant loading	The changes in plaque index after implant loading. Plaque index was recorded for determining and classifying oral hygiene status.
Gingival index	Baseline and 1, 3 and 6 months after implant loading	The changes in gingival index after implant loading. Gingival index was recorded for classifying and evaluating gingival inflammation.
Probing depth	Baseline and 1, 3 and 6 months after implant loading	The changes in probing pocket depth after implant loading.Probing pocket depth was measured for determining periimplant health.
Bleeding on probing	Baseline and 1, 3 and 6 months after implant loading	The changes in bleeding on probing after implant loading. Bleeding on probing was recorded for evaluating gingival inflammation.