Department of Anesthesiology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.
试验速览
- 阶段
- 不适用
- 入组人数
- 80
- 主要终点
- global inhomogeneity (GI)
研究概览
简要总结
Two-handed mask ventilation has been shown to provide higher tidal volume than one-handed mask ventilation. The effects of the two techniques on respiratory mechanics during induction of general anesthesia, however, still need to be determined.
详细描述
Mask positive pressure ventilation always causes the changes of respiratory mechanics such as ventral redistribution of regional ventilation, which impairs gas exchange. Two-handed mask ventilation has been shown to improve gas exchange by providing higher tidal volume than one-handed mask ventilation. We hypothesis that those higher tidal volume caused by two-handed mask ventilation would also improve the respiratory mechanics during induction of general anesthesia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Scheduled for elective surgery with general anesthesia
- •American Society of Anesthesiologist (ASA) physical class of I-II.
排除标准
- •acute and chronic respiratory disorders, including chronic obstructive
- •pulmonary disease (COPD) and asthma;
- •a history of lung surgery;
- •exist risk of reflux and aspiration;
- •patients requiring an awake intubation;
- •facial and thoracic deformities;
- •implants exist in the body, such as cardiac pacemakers;
- •pregnant women.
结局指标
主要结局
global inhomogeneity (GI)
时间窗: 8 weeks
EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. 0% = homogenous
次要结局
- regional ventilation delay (RVD)(8 weeks)
- Expiratory tidal volume (TV)(8 weeks)
- PaO2/FiO2(8 weeks)
- centre of ventilation (CoV)(8 weeks)
- ventilation of regional lung ( %)(8 weeks)