Effects of One-handed and Two-handed Mask Ventilation Techniques on Global and Regional Lung Ventilation

Not Applicable

• Conditions: Anesthesia

• Registration Number: NCT04617665
• Lead Sponsor: Fudan University

Brief Summary

Two-handed mask ventilation has been shown to provide higher tidal volume than one-handed mask ventilation. The effects of the two techniques on respiratory mechanics during induction of general anesthesia, however, still need to be determined.

Detailed Description

Mask positive pressure ventilation always causes the changes of respiratory mechanics such as ventral redistribution of regional ventilation, which impairs gas exchange. Two-handed mask ventilation has been shown to improve gas exchange by providing higher tidal volume than one-handed mask ventilation. We hypothesis that those higher tidal volume caused by two-handed mask ventilation would also improve the respiratory mechanics during induction of general anesthesia.

Study Timeline

• Status Verified: 2020-10
• Study First Submitted: 2020-10-25
• Study Start: 2020-11
• Study First Submitted QC: 2020-11-04
• Last Update Submitted: 2020-11-04
• Study First Posted: 2020-11-05
• Last Update Posted: 2020-11-05
• Primary Completion: 2020-12
• Study Completion: 2020-12

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• Scheduled for elective surgery with general anesthesia
• American Society of Anesthesiologist (ASA) physical class of I-II.

Exclusion Criteria

• acute and chronic respiratory disorders, including chronic obstructive
• pulmonary disease (COPD) and asthma;
• a history of lung surgery;
• exist risk of reflux and aspiration;
• patients requiring an awake intubation;
• facial and thoracic deformities;
• implants exist in the body, such as cardiac pacemakers;
• pregnant women.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
global inhomogeneity (GI)	8 weeks	EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. 0% = homogenous

Secondary Outcome Measures

Name	Time	Method
regional ventilation delay (RVD)	8 weeks	EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data.
Expiratory tidal volume (TV)	8 weeks	Expiratory tidal volume will be recorded through the anesthesia machine.
PaO2/FiO2	8 weeks	PaO2/FiO2 will be recorded through arterial blood gas analysis.
centre of ventilation (CoV)	8 weeks	EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data. 100% = entirely dorsal.
ventilation of regional lung ( %)	8 weeks	EIT images will be acquired by using the EIT monitor (Drager Medical Gmbh, Lubeck, Germany). And a software package (Electrical impedance tomography diag custom software provided by Drager Medical) will be used to quantitatively analyze the EIT data.