Genetic Susceptibility Factors for Candidemia.
Completed
- Conditions
- Invasive CandidiasisCandidemiaGenetic Predisposition to Disease
- Interventions
- Genetic: Analysis of genetic polymorphisms
- Registration Number
- NCT02841501
- Lead Sponsor
- University Hospital, Lille
- Brief Summary
This is a prospective case-control physiopathological study, which main objective is to determine the genetic host factors predisposing to candidemia. Secondary objectives are to develop new diagnosis tools using the biological collection, to describe and update epidemiology, to analyse the influence of genetic polymorphisms on prognosis.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 453
Inclusion Criteria
- Patient older than 18 years.
- Informed consent.
- Positive blood culture with isolation of Candida sp.
Exclusion Criteria
- No informed consent.
- Patient younger than 18.
- No insurance coverage.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Candidemia patients Analysis of genetic polymorphisms These patients are included in the study after the reception of a positive blood culture for Candida sp. Control patients Analysis of genetic polymorphisms These patients are matched on case patients on the following criteria: * Age+/-5 years * length of hospitalisation * type of ward * type of surgery for surgical patients * IGS2 for intensive care patients
- Primary Outcome Measures
Name Time Method Frequency of the polymorphisms between the groups In the 48-72 hours following the positive blood culture
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Hôpital Salengro, Intensive care departement, CHRU
🇫🇷Lille, France