Synthetic THC And Blood Pressure
- Registration Number
- NCT07231965
- Lead Sponsor
- Mayo Clinic
- Brief Summary
To investigate the effects of Dronabinol use on blood pressure and neurovascular physiology
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- NOT_YET_RECRUITING
- Sex
- All
- Target Recruitment
- 50
Not provided
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description Dronabinol Group Dronabinol Patients taking Dronabinol first and Placebo second Dronabinol Group Placebo Patients taking Dronabinol first and Placebo second Placebo Group Dronabinol Patients taking Placebo first and Dronabinol second Placebo Group Placebo Patients taking Placebo first and Dronabinol second
- Primary Outcome Measures
Name Time Method Blood Pressure Baseline, 30 days Blood pressure is the force exerted by circulating blood on the walls of the arteries as it is pumped through the body. Blood pressure will be measured as a ratio of systolic/diastolic (mmHg).
Heart Rate Baseline, 30 days Heart Rate is the number of contractions (beats) that the heart makes per minute. This will be measured in bpm (beats per minute)
- Secondary Outcome Measures
Name Time Method Flow Mediated Dilation Baseline, 30 days Flow Mediated Dilation will be measured by ultrasonography of brachial artery, reported as an absolute change in arterial diameter from resting baseline
Aortic Wave Reflection Baseline, 30 days Aortic Wave Reflection will be measured via arterial tonometry, reported as aortic augmentation index
Baroreflex Sensitivity Baseline, 30 days Baroreflex sensitivity will be assessed using beat-by-beat blood pressure, heart rate, and Sympathetic nerve activity collected continuously for at least 5min. This will be measured in ms/mmHg.
Sympathetic control Baseline, 30 days Sympathetic control will be measured by microneurography of peroneal or fibular nerve, reported as bursts of sympathetic activity per minute or normalized to 100 heart beats
Trial Locations
- Locations (1)
Mayo Clinic in Rochester
🇺🇸Rochester, Minnesota, United States
Mayo Clinic in Rochester🇺🇸Rochester, Minnesota, United States