Validation of German versions of the Cerebellar Cognitive Affective Syndrome Scale in patients with degenerative and focal cerebellar disorders.

Recruiting

• Conditions: degenerative ataxias, focal cerebellar lesions after hemorrhage, ischaemic stroke, tumor or surgery on/in the cerebellum; I63; R27.0; G11; D33; C71; Cerebral infarction; Ataxia, unspecified; Hereditary ataxia; Benign neoplasm of brain and other parts of central nervous system

• Registration Number: DRKS00016854
• Lead Sponsor: eurologische Klinik, Universitätsklinikum Essen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2019-03-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 600

Inclusion Criteria

1. Written consent.
2. Minimum age 18 years.
3. German-speaking.

Exclusion Criteria

1. Healthy control subjects: Neurological disorders (inclusive epileptic seizures) or psychiatric conditions.
2. Patients: Severe psychiatric conditions.
3. Drug or alcohol abuse.
4. Intake of centrally acting drugs.
5. Persons with consuming disorders and in reduced general health condition.
6. (Adult) persons that have a legal guardian and that are not contractually capable.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Validation of the versions A-D of the German CCAS Scale.<br><br>After data acquisition the following parameters are determined for this purpose:<br><br>- re-test-reliability<br>- interrater-reliability<br>- parallel-test-reliability<br>- internal consistency<br>- construct-validity<br>- sensitivity<br>- specifity

Secondary Outcome Measures

Name	Time	Method
1. Pattern of cognitive/affective deficits in different cerebellar disorders<br>2. Correlation of cognitive/affective deficits in patients with focal cerebellar lesions to lesion sites shown by MRI (lesion-symptom-mapping) in following trials