The Effect of Phototherapy on Pruritus of Patients With Chronic Kidney Disease

Not Applicable

Completed

• Conditions: Uremic Pruritus
• Interventions: Device: Narrow band UVB phototherapy , long wave UVA phototherapy

• Registration Number: NCT00494975
• Lead Sponsor: National Taiwan University Hospital

Brief Summary

The purpose of this study was to confirm the efficacy of NB UVB phototherapy in alleviating uremic pruritus and investigate the association between improvement of pruritus and change of serum parameters, including routine biochemical data, immune profile and dialysis adequacy.

Detailed Description

We would conduct a randomized study to evaluate the effect of NB UVB therapy on uremic pruritus. The intensity of pruritus will be evaluated using visual analog scale (VAS) score (0 \[no pruritus\]-10 most severe pruritus\]) and a detailed questionnaire assessing various characteristics of pruritus at baseline . The patients with the intensity of pruritus VAS score more than 5 will be randomized to narrow band UVB and control group. Phototherapy was administered to the whole body surface 2-3 sessions per week for total 18 sessions in a UV irradiation cubicle. The dose increased from 210mJ/cm2 .Doses were increased by 10 % at every session. The control group received time-matched exposures to long-wave ultraviolet light. The investigator will determine the pruritic intensity at baseline every 3 sessions by VAS score and by detailed questionnaire at baseline and after 18 sessions. The blood sample will also be collected at baseline and after treatment to determine factors associated with improvement.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2007-06
• Study First Submitted: 2007-06-29
• Study First Submitted QC: 2007-06-29
• Study First Posted: 2007-07-02
• Primary Completion: 2009-07
• Study Completion: 2009-07
• Status Verified: 2010-09
• Results First Submitted: 2010-10-05
• Results First Submitted QC: 2011-01-06
• Results First Posted: 2011-01-25
• Last Update Submitted: 2011-01-26
• Last Update Posted: 2011-01-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 21

Inclusion Criteria

• Chronic kidney disease with moderate to severe uremic pruritus for longer than 2 months

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Exclusion Criteria

• pregnancy history of photosensitivity photo-aggravated disease

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
NB-UVB	Narrow band UVB phototherapy , long wave UVA phototherapy	Narrow band-Ultraviolet B phototherapy
UVA	Narrow band UVB phototherapy , long wave UVA phototherapy	Ultraviolet A Phototherapy

Primary Outcome Measures

Name	Time	Method
Visual Analogue Scale (VAS) Score for Pruritus	VAS score at baseline and after 6 -week phototherapy	a VAS is a horizontal line, 100 mm in length. The patient marks on the line the point that they feel represents their perception of their pruritus.; 0 (no pruritus) - 10 (most severe pruritus) The investigator will determine the pruritic intensity at baseline, every 3 sessions by VAS score, and by detailed questionnaire at baseline and after 18 sessions

Secondary Outcome Measures

Name	Time	Method
Detailed Questionnaire at Baseline and After 18 Sessions	at baseline and after 18 sessions

Trial Locations

Locations (1)

Department of dermatology, National Taiwan Univeristy Hospital Yun-Lin branch; 🇨🇳 Douliou City, Yunlin County, Taiwan