Immune micro-environment and immune genomics of head and neck cancer
Not Applicable
- Conditions
- Health Condition 1: null- Patients with Gingivo buccal-Oral squamous cell carcinoma
- Registration Number
- CTRI/2018/07/014757
- Lead Sponsor
- Department of Biotechnology Systems Medicine Cluster SyMeC Kolkata
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Closed to Recruitment of Participants
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
Newly diagnosed locally advanced Oral Gingivo-Buccal Complex Squamous Carcinomas, as defined by the TNM Classification of AJCC 8th Edition, who have consented for being included in the study and will are eligible to receive standard of care institutional practise for the disease and periodic follow up thereafter.
Exclusion Criteria
Early stage patients (TNM stage 1 and 2 ) and patients who have received prior treatment will be excluded.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The study will help us characterize the immune and genomic profile, specifically T cell repertoire, of OSCC-GB in a uniform cohort of patients, using the selected methodology.Timepoint: 1st one year
- Secondary Outcome Measures
Name Time Method By following up this uniform cohort of patients regularly, we will explore the association between the immune profile and patient outcomes, as a result we hope to develop a potential prognostic and /or predictive group of immune biomarkers. These biomarkers can be used for next generation of biomarker evaluation studies and developing immune prognostic signatures.Timepoint: Two years