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Clinical Trials/NCT05631743
NCT05631743
Recruiting
Not Applicable

A Virtual Reality-assisted Cognitive Behavior Therapy with Inuit in Quebec - a Proof-of-concept Randomized Controlled Trial

Douglas Mental Health University Institute1 site in 1 country40 target enrollmentJuly 15, 2023

Overview

Phase
Not Applicable
Intervention
Not specified
Conditions
Emotion Regulation
Sponsor
Douglas Mental Health University Institute
Enrollment
40
Locations
1
Primary Endpoint
Emotion Regulation
Status
Recruiting
Last Updated
last year

Overview

Brief Summary

The study design is a two-arm randomized controlled pilot trial. The investigators will recruit Inuit in Montreal and randomly assign them to two treatment groups (n=20 each). The active psychotherapy group will receive a ten-week manualized virtual reality (VR) assisted cognitive-behavioral psychotherapy (VR-CBT) at the clinic and guided by a psychotherapist. The VR-CBT will aim at improving emotion regulation. The comparison group will use a VR self-management program, Calm Place, for guided relaxation during ten weeks at home. To evaluate outcome in both groups, the researchers will measure self-reports of emotion regulation, affect, distress and well-being, as well as a psychophysiological reactivity paradigm pre-post treatment.

Detailed Description

In this protocol, the investigators present a proof-of-concept trial that will evaluate an active psychotherapy and self-management, both targeting emotion regulation skills. The study design is a two-arm randomized controlled trial. The investigators will recruit Inuit and randomly assign them to two treatment groups (n=20 each). The active psychotherapy group will receive a ten-week manualized virtual reality (VR) assisted cognitive-behavioral psychotherapy (VR-CBT) at the clinic and guided by a psychotherapist. The VR-CBT will aim at improving emotion regulation, a set of skills or competence that is impacted by traumatic experiences and mediates the effect of trauma on psychiatric symptoms. The investigators conducted a cultural adaptation of the therapy for Inuit with a co-design grounded in qualitative participatory methods. The comparison group will use a VR self-management program, Calm Place, for guided relaxation during ten weeks at home. To evaluate outcome in both groups, the researchers will include a psychophysiological reactivity paradigm pre-post treatment and self-reports of emotion regulation, anxiety, mood, substance use, functionality and quality of life. The investigators expect to see preliminary evidence that our VR-CBT can be more successful than guided VR relaxation with Calm Place (self-management) decreasing difficulties in emotion regulation, psychiatry symptoms, increasing well-being, and normalizing responses to stressful stimuli (reactivity).

Registry
clinicaltrials.gov
Start Date
July 15, 2023
End Date
December 31, 2025
Last Updated
last year
Study Type
Interventional
Study Design
Parallel
Sex
All

Investigators

Responsible Party
Principal Investigator
Principal Investigator

Martin Lepage

James McGill professor

Douglas Mental Health University Institute

Eligibility Criteria

Inclusion Criteria

  • Self-identify as Inuk
  • Live in Montreal
  • be between 14 to 60 years of age
  • be proficient in English or French
  • No history of cardiac conditions
  • No history of epilepsy
  • Can provide an emergency contact
  • Tolerance of VR headset
  • Tolerance of sensors
  • Has no current suicidal or homicidal risk

Exclusion Criteria

  • does not identify as Inuk
  • youth below the age of 14 and adults above the age of
  • self-reported history of psychosis or schizophrenia
  • current substance abuse, as measured by two screens (AUDIT-C, DAST-10)
  • other mental or physical condition that might preclude them from the trial (i.e., pre-existing heart conditions, convulsions, acute mental health risk).

Outcomes

Primary Outcomes

Emotion Regulation

Time Frame: Approximately 5 minutes

Difficulties in Emotion Regulation Scale-16 is a short, valid measure of emotion regulation, scored from 16(low difficulties)-80 (higher difficulties).

Secondary Outcomes

  • emotional valence (momentary)(Approximately 1 hour testing session.)
  • Psychiatric Symptoms (alcohol use disorder)(Administration time is between 2 minutes)
  • Psychological distress and well being: Clinical outcome in routine evaluation outcome measure and 10 item (CORE- OM/10)(Approximately 10 minutes)
  • Feasibility of interventions (attendance/useage)(10 weeks of intervention period (researcher recorded))
  • Psychological distress and well being: Short/ Warwick Edinburgh Mental Wellbeing Scale(Approximately 10 minutes)
  • skin conductance response(Approximately 1 hour testing session.)
  • heart rate(Approximately 1 hour testing session.)
  • anxiety (momentary)(Approximately 1 hour testing session.)
  • heart rate variability(Approximately 1 hour testing session.)
  • Psychiatric Symptoms (anxiety)(Administration time is around 3 minutes)
  • emotional arousal (momentary)(Approximately 1 hour testing session.)
  • Psychiatric Symptoms (depression)(Administration time is around 4 minutes)
  • Psychiatric Symptoms (post traumatic stress disorder)(Administration time is between 2 minutes)
  • Psychiatric Symptoms (substance use disorders)(Administration time is between 4 minutes)
  • Feasibility of interventions (treatment completion)(10 weeks of intervention period (researcher recorded))

Study Sites (1)

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