Influences of antibiotics on biodiversity of intestinal microbiota in newborns

• Conditions: intestinal flora; Microbiota; 10017966; 10004018

• Registration Number: NL-OMON33555
• Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 6 May 2024

Recruitment & Eligibility

• Status: Pending
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

Inclusion criteria Group 1
• Newborn infants born by vaginal delivery
• Without any complications during both intrauterine and intra partum period
• No antenatal/postnatal antibiotics
• Normal healthy infant
• Breastfed;Inclusion criteria Group 2
• Newborn infants born by vaginal delivery
• Without complications during both intrauterine and intra partum period except minor risk factors (GBS colonisation, unknown GBS status, Temp < 39°C) to prescribe antenatal antibiotics to the mother
• Antenatal antibiotics I.V. (2-8 hours before delivery)
• No postnatal antibiotics
• Normal healthy infant
• Breastfed;Inclusion criteria Group 3
• Newborn infants born by vaginal delivery
• Without any complications during both intrauterine and intra partum period
• No antenatal antibiotics
• Postnatal antibiotic therapy started within first 12 hours after birth and discontinued within 48-72 hours (discontinued course of antibiotics).
• Normal healthy infant with low risk for early onset sepsis
• Breastfed;Inclusion criteria Group 4
• Newborn infants born by vaginal delivery
• Without any complications during both intrauterine and intra partum period
• No antenatal antibiotics
• Postnatal antibiotic therapy started within first 12 hours after birth and discontinued after one week (full course of antibiotics).
• Normal healthy infant in whom an early onset sepsis could not be excluded.
• Breastfed;Inclusion criteria Group 5
• Newborn infants born by cesarean section
• Without any complications during both intrauterine and intra partum period
• No antenatal/postnatal antibiotics
• Normal healthy infant
• Breastfed

Exclusion Criteria

- APGAR Score after 5 minutes < 6
- Major congenital abnormality
- Congenital abnormonality of gastro intestinal tract

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Biodiversity of intestinal microbiota in newborns. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>The quantity of the specific bacteria in the intestinal microbiota of the<br /><br>newborn infant. </p><br>