Oral Nifedipine Versus Labetalol in Treatment of Postpartum Hypertension
试验速览
- 阶段
- 4 期
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- control blood pressure
研究概览
简要总结
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure >140/90 mmhg) in pregnancy is classified into one of four conditions
- chronic hypertension that precedes pregnancy
- pre eclampsia and eclampsia: a systematic syndrome of elevated arterial pressure,proteinuria and other findings
- pre eclampsia superimposed upon chronic hypertension
- gestational hypertension or nonproteinuric hypertension of pregnancy
详细描述
Hypertensive disorders of pregnancy are important cause of severe morbidity, long-term disability and death among both mothers and their babies. In Africa and Asia, nearly one tenth of all maternal deaths are associated with hypertensive disorders of pregnancy research has focused on the antenatal complications' for both mother and baby and the risks and benefits of administering antihypertensive therapy prior to delivery hypertension disorders of pregnancy often persist following delivery and sometimes arise de novo postpartum one of the maternal complications of pre eclampsia is residual chronic hypertension in about 1/3 of cases elevated blood pressure is seen in 6%to 8% of all pregnancies hypertension (arterial pressure >140/90 mmhg) in pregnancy is classified into one of four conditions
- chronic hypertension that precedes pregnancy
- pre eclampsia and eclampsia: a systematic syndrome of elevated arterial pressure,proteinuria and other findings
- pre eclampsia superimposed upon chronic hypertension
- gestational hypertension or nonproteinuric hypertension of pregnancy evaluate the effectiveness, safety and acceptability of Oral nifedipine versus oral labetalol in treatment of persistent postpartum hypertension
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Women who have hypertension during pregnancy and persist after delivery till discharge of hospital about 2 days of monitoring the blood pressure
排除标准
- •Women with history of secondary hypertension Women with eclampsia who need intensive care unit admission and indicated other drugs rather than oral nifedipine and oral labetalol Women who have any contraindication to Nifedipine or labetalol
研究组 & 干预措施
take oral nifedipine tablets
Women who take the oral tablets of nifedipine till discharge of hospital
干预措施: Oral Tablet (Drug)
take oral labetalol tablets
Women who take the oral tablets of labetalol till discharge of hospital
干预措施: Oral Tablet (Drug)
结局指标
主要结局
control blood pressure
时间窗: till discharge of hospital about two days
duration,total dose to achieve blood pressure below the critical value between 140 and 150 mmHg systolic and 90-100 mmHg diastolic by monitoring of blood pressure
次要结局
- Improvement of hematological values(till discharge of hospital about two days)
- Side effects in both groups(till discharge of hospital about two days)
- Improvement of other investigations(till discharge of hospital about two days)
- Resolution of complications(till discharge of hospital about two days)
研究者
Hossam Ahmed Abd Ellah
Principal investigator
Assiut University