Effects of ketone supplementation on recovery from endurance exercise in recreationally active males

Not Applicable

• Conditions: Skeletal muscle recovery; Musculoskeletal - Normal musculoskeletal and cartilage development and function

• Registration Number: ACTRN12623000184673
• Lead Sponsor: Dr Jamie Whitfield

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-02-21
• Last Update Posted: 27 February 2023

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Participants will be recruited if they meet the following criteria:
•Male
•Aged 18-35 y
•BMI: 18.5-24.9 kg/m2
•Recreationally active (A-B grade cyclists or triathletes currently cycling ~200km/week) capable of completing the 180 min intermittent intensity exercise protocol
•No cardiopulmonary abnormalities
•No injuries
•Pass the ESSA pre-exercise screening tool and/or obtain GP clearance to exercise

Exclusion Criteria

•Known cardiovascular disease or diabetes mellitus
•Known bleeding disorder (i.e. hemophilia A [factor VIII deficiency]
•Hemophilia B [factor IX deficiency]
•von Willebrand disease, or other rare factor deficiencies including I, II, V, VII, X, XI, XII and XIII)
•Major or chronic illness that impairs mobility or eating/digestion
•Taking prescription medications (i.e. beta-blockers, anti-arrhythmic drugs, statins, insulin sensitising drugs, or drugs that increase the risk of bleeding [i.e. anticoagulants, antiplatelets, novel oral anticoagulants [NOAs], nonsteroidal anti-inflammatory drugs [NSAIDs], selective norepinephrine reuptake inhibitors [SNRI], or selective serotonin reuptake inhibitors [SSRIs]
•Unable or unwilling to have a muscle biopsy
•Weight has changed more than 5kg in past 3 months
•Currently on a restrictive diet
•Unable to attend the lab in Fitzroy, Melbourne for the 4 study visits for completion of study protocol

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rates of skeletal muscle protein synthesis (expressed as fractional synthetic rate (FSR in %/h), as measured by incorporation of L-[ring-(13)C(6)]-phenylalanine tracer in muscle biopsy samples as described previously (Smiles et al. 2019, PMID: 30840513).[Post exercise skeletal muscle FSR will be determined from muscle biopsies taken immediately post exercise (t=o) and 2 (t=120 min) and 5 h (t=300 min) into the recovery period.]