Clinical Efficacy of Safoof Marzanjosh (Origanum majorana) in Hyperlipidemia - A Randomized Controlled Trial

Unani system of medicine is one of the oldest systems of medicine which is practiced worldwide as holistic, preventive and curative medicine.In Unani Medicine, humours (Akhlat) play a vital role in maintenance of health; imbalance of their proportion either qualitative or quantitative can cause disease. Akhlat refers to the body fluids under a wider perspective in the Unani Medicine based upon theory of humors, which presupposes the presence of four humors in the body: dam (blood), balgham (phlegm), safra (yellow bile), and sawda (black bile), and human body is made of ten types of Aza_e_muffarada of which Shahm (Fat) is one of the important constituents.  Unani literature has classified Shaham  (Fat) under various categories like Sameen and Rivaaj1.  Unani system has mentioned a number of functions of Shaham which corelates with modern system of medicine such as it gives energy and creates heat, helps to store energy, gives shape and protects our vital organs.Lipids(fat) are water insoluble molecules that are transported in protein capsule, which determines its density, the lipoproteins density determines the fate of the particle and its influence on metabolism.  Plasma lipoprotein levels are major modifiable risk factors for cardiovascular disease. Increased levels of atherogenic lipoproteins (especially LDL) contribute to the development of atherosclerosis. LDL-C (Low density Lipoproteins)

The cost of management of hyperlipidemia throughout the world is high.In 2010, the estimated global cost of treatment of Hyperlipidemia was USD 863 billion, which is expected to increase to USD 1044 billion by the year 203010.  But in Unani System of Medicine there are plenty of potential herbal drugs which are safe and cheaper in comparison with modern drugs. Hence an attempt is made to explore the abundant resources of Unani Medicine in management of Hyperlipidemia.