The effect of Lubisprostone on gut microbiota in patients with chronic functional constipation and its auxiliary role in colonoscopy examination
Not Applicable
- Conditions
- Chronic functional constipation
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria
- Age range from 18 to 75 years old;<br>2) Complies with the diagnostic criteria for chronic functional constipation in the Chinese Chronic Constipation Diagnosis and Treatment Guidelines (2013, Wuhan)
Exclusion Criteria
- Constipation caused by organic intestinal diseases such as intestinal tumors, intestinal stenosis or obstruction, megacolon, intestinal torsion, rectal prolapse, etc;<br>2) Constipation caused by endocrine and metabolic diseases such as severe dehydration, uncontrollable diabetes, uncontrollable thyroid and parathyroid dysfunction, multiple endocrine adenoma, heavy metal poisoning, hypercalcemia, high or low magnesium, hypokalemia, porphyria, chronic kidney disease, uremia, etc;<br>3) Constipation caused by neurological diseases such as autonomic neuropathy, cerebrovascular disease, cognitive impairment or dementia, multiple sclerosis, Parkinson's disease, spinal cord injury, etc;<br>4) Constipation caused by muscle diseases such as amyloidosis, dermatomyositis, scleroderma, systemic sclerosis, etc;<br>5) Constipation caused by drugs such as antidepressants, antiepileptics, antihistamines, antipsychotic drugs, antispasmodic drugs, calcium antagonists, diuretics, monoamine oxidase inhibitors, opioids, sympathetic nervous system drugs, aluminum or calcium containing antacids, calcium, iron, antidiarrheals, non steroidal anti-inflammatory drugs, etc;<br>6) Pregnancy;<br>7) Allergies to Lubiprostone, polyethylene glycol, and silicone oil;<br>8) Take antibiotics, acid suppressants, bismuth supplements, probiotics, etc. within the past 3 months;<br>9) Inability to tolerate colonoscopy, coagulation, platelet abnormalities unsuitable for biopsy, and other situations deemed unsuitable for inclusion in the study by researchers.
Study & Design
- Study Type
- Interventional study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The effect of Lubisprostone on gut microbiota in patients with chronic functional constipation after treatment and colonoscopy examination;The effect of Lubisprostone on intestinal barrier function after colonoscopy in patients with chronic functional constipation.;
- Secondary Outcome Measures
Name Time Method The effect of Lubisprostone on symptoms and quality of life in patients with constipation;The effect of Lubisprostone combined with polyethylene glycol on intestinal preparation in patients with chronic functional constipation;