Safety and Efficacy of High Flow Nasal Canula in Patients With Mild Hypercapnia

Not Applicable

Completed

• Conditions: Hypercapnia

• Registration Number: NCT05948527
• Lead Sponsor: Mansoura University

Brief Summary

Evaluate safety and efficacy of application ( high flow nasal canula) in cases with mild hypercapnia, included 30 patients who were hospitalized in Mansoura University chest department with mild Hypercapnia (Pco2 range 45-60 mmhg and power of hydrogen not less 7.30) of different pulmonary disease categories (Chronic obstructive pulmonary disease acute exacerbation, pneumonia, Interstitial lung diseases, etc).

Detailed Description

Not available

Study Timeline

• Study Start: 2023-01-01
• Status Verified: 2023-06
• Study First Submitted: 2023-06-24
• Primary Completion: 2023-07-01
• Study Completion: 2023-07-01
• Study First Submitted QC: 2023-07-13
• Last Update Submitted: 2023-07-13
• Study First Posted: 2023-07-17
• Last Update Posted: 2023-07-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• patients with mild Hypercapnia

Exclusion Criteria

• Excluded cases had age less than 18 years or pediatric group .
• patients with their mental state altered, confused, comatose, severe agitation or non cooperative
• Cases with moderate or severe Hypercapnia
• cases in need for immediate invasive mechanical ventilation
• cases with respiratory rate more than 35 breath per minute.
• cases with Respiratory exhaustion , fatigue , excess use of respiratory accessory muscles
• Shock , hemodynamic instability, post arrest cases,
• cases with facial trauma or severe nasal deformity,
• Patients with sleep breathing disorders or upper airway obstruction
• patients with history of home ventilation prior admission

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
Arterial Blood Gases changes	48 hours	The primary outcome was concerned about changes in Arterial Blood Gases in first 24 h after admission and the same changes 48 h after admission.

Secondary Outcome Measures

Name	Time	Method
Number of participants in need for ventilation	7 days	Secondary outcome was concerned about need to non invasive mechanical ventilation or invasive mechanical ventilation.

Trial Locations

Locations (1)

Mansoura University Hospitals; 🇪🇬 Mansoura, Dakahlia Governorate, Egypt