HFNC and Prone Positioning in Awake Patients With Severe COVID-19

Completed

• Conditions: Hypoxemic Respiratory Failure

• Registration Number: NCT04982341
• Lead Sponsor: Hôpital Universitaire Fattouma Bourguiba

Brief Summary

The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.

Detailed Description

The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.

All patients with ARF related to Covid-19 and admitted to the ICU are turned in prone position whenever tolerated, while receiving oxygenation with HFNC.

Outcomes of interest are the rate of success or failure (defined as the need for intubation and mechanical ventilation)

Study Timeline

• Study Start: 2020-09-02
• Primary Completion: 2021-03-03
• Study Completion: 2021-03-03
• Status Verified: 2021-07
• Study First Submitted: 2021-07-19
• Study First Submitted QC: 2021-07-28
• Last Update Submitted: 2021-07-28
• Study First Posted: 2021-07-29
• Last Update Posted: 2021-07-29

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• aged ≥18 years, admitted to the medical ICU for confirmed Covid-19 and acute hypoxemic respiratory failure

Exclusion Criteria

• patients already intubated at admission or those requiring immediate intubation

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Number of patients without intubation	through study completion, an average of 28 days	successful oxygenation without intubation

Trial Locations

Locations (1)

CHU F.Bourguiba; 🇹🇳 Monastir, Tunisia