Primary Ovarian Insufficiency, Polycystic Ovary Syndrome & the CardiOvascular Risk Profile
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiovascular Diseases
- Sponsor
- UMC Utrecht
- Enrollment
- 125
- Locations
- 1
- Primary Endpoint
- carotid intima media thickness
- Status
- Completed
- Last Updated
- 7 years ago
Overview
Brief Summary
The polycystic ovary syndrome (PCOS) is the most common endocrinopathy amongst women of reproductive age. PCOS is associated with various cardiovascular risk factors such as obesity, glucose intolerance, dyslipidemia hypertension and the metabolic syndrome. Whether these increased cardiovascular risk factors result in the development of actual cardiovascular disease in later life remains to be established.
Women with premature ovarian insufficiency (POI), experience menopause prior to the age of 40 years. Women with POI may exhibit dyslipidemia. A young age at menopause has been previously associated with increased cardiovascular morbidity and mortality.
Detailed Description
Cardiovascular risk profile will be assessed in women with PCOS and POI \> 45 years of age, consisting of: fasting serum and urine analyses blood pressure, length, weight, waist circumference, hip circumference ECG carotid intima media thickness cardiac ultrasound spare serum, plasma and urine will be stored in -80 degrees celsius biobank.
Investigators
Bart CJM Fauser
professor
UMC Utrecht
Eligibility Criteria
Inclusion Criteria
- •age above 45 years
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
carotid intima media thickness
Time Frame: 10 years post diagnosis
ultrasound measurement of thickness of carotid wall (mean IMT), presence of atherosclerotic plaques (yes/no, location)
Secondary Outcomes
- insulin and glucose levels(10 years post diagnosis)
- dyslipidemia(10 years post diagnosis)
- electrocardiogram (ECG)(10 years post diagnosis)
- C-reactive protein(10 years post diagnosis)
- homocysteine(10 years post diagnosis)
- uric acid(10 years post diagnosis)
- androgen levels(10 years post diagnosis)
- cardiac ultrasound (hypertrophy)(10 years post diagnosis)