Enzymatic and proteomic salivary bio markers for erosio

• Conditions: K03.2; Erosion of teeth

• Registration Number: DRKS00012395
• Lead Sponsor: Stiftungsprofessur für Kariesforschung Klinik für Zahnerhaltungskunde und Parodontologie Department f. Zahn-, Mund- u. KieferheilkundeUniversitätsklinikum Freiburg

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2017-10-18
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

age of consent; informed written consent; Groups suffering from erosion: BEWE
score of at least 2 in at least two sextants

Exclusion Criteria

cavitated carious lesions; insufficient fillings reaching the dentine; deep and
inflamed periodontal pockets (= 4 mm with bleeding); other serious inflammatory
processes in the oral cavity; allergy against the used dental materials

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Single measurement of the activity of oral proteolytic enzymes (pepsin, trypsin, salivary collagenases, common proteolytic activity) with standard test kits; Single analysis of the saliva proteom; Correlation of the activity and the protein composition with the type of the impacting acid and the occurrence of erosion according to BEWE criteria in the different groups

Secondary Outcome Measures

Name	Time	Method
Association of basic salivary parameter, nutrition data, medication and nutrition in the context of an eating disorder with occurence and severity of erosion.