Sebum Collection and Skin Barrier Function Analysis

Completed

• Conditions: Smoking; Aging; Acne; Atopic Dermatitis
• Interventions: Other: Skin Surface Lipid Collection and Skin Barrier Function

• Registration Number: NCT03112876
• Lead Sponsor: University of California, Davis

Brief Summary

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population

2. Atopic dermatitis vs Acne vs Healthy controls

3. Active smokers vs non-smoker controls

Detailed Description

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-06-27
• Study First Submitted: 2014-07-10
• Primary Completion: 2016-02-26
• Study Completion: 2016-02-26
• Status Verified: 2017-04
• Study First Submitted QC: 2017-04-07
• Last Update Submitted: 2017-04-07
• Study First Posted: 2017-04-13
• Last Update Posted: 2017-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Subjects that are 12 years of age or older

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Exclusion Criteria

• None

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Young Age - Healthy	Skin Surface Lipid Collection and Skin Barrier Function	These subjects are between the age of 12 and 35 years. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Old Age -Healthy	Skin Surface Lipid Collection and Skin Barrier Function	These subjects are 55 years of age and older. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Dermatological skin condition: Acne vulgaris	Skin Surface Lipid Collection and Skin Barrier Function	These subjects have acne vulgaris. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Dermatological skin condition: Atopic dermatitis	Skin Surface Lipid Collection and Skin Barrier Function	These subjects have atopic dermatitis. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.
Active Smoker	Skin Surface Lipid Collection and Skin Barrier Function	These subjects are active smokers who smoke often. This group will undergo the following intervention: skin surface lipid collection via tapes and skin barrier function evaluated with non-invasive painless devices.

Primary Outcome Measures

Name	Time	Method
Lipid Profile-aging	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-acne	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-atopic dermatitis	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-smoking	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

Secondary Outcome Measures

Name	Time	Method
Skin Barrier Function- aging	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- acne	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- atopic dermatitis	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- smoking	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

Trial Locations

Locations (1)

UC Davis Department of Dermatology; 🇺🇸 Sacramento, California, United States