Sebum Collection and Skin Barrier Function Analysis

Completed

• Conditions: Smoking; Aging; Acne; Atopic Dermatitis

• Registration Number: NCT03112876
• Lead Sponsor: University of California, Davis

Brief Summary

The goal is this study is to evaluate how the skin surface lipid composition is correlated with overall sebum production, barrier function, and inflammatory disease status. We hypothesize that there will be differences in the skin surface composition among subjects of various groups:

1. Young vs older healthy population

2. Atopic dermatitis vs Acne vs Healthy controls

3. Active smokers vs non-smoker controls

Detailed Description

This study will be conducted through the use of painless tapes to collect lipid. These will be applied to the skin and removed. Secondly, the barrier function will be evaluated through the use of non-invasive painless devices that measure sebum, skin water loss, and skin hydration.

Study Timeline

• Study Start: 2014-06-27
• Study First Submitted: 2014-07-10
• Primary Completion: 2016-02-26
• Study Completion: 2016-02-26
• Status Verified: 2017-04
• Study First Submitted QC: 2017-04-07
• Last Update Submitted: 2017-04-07
• Study First Posted: 2017-04-13
• Last Update Posted: 2017-04-13

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 41

Inclusion Criteria

• Subjects that are 12 years of age or older

Exclusion Criteria

• None

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Lipid Profile-aging	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-acne	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-atopic dermatitis	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.
Lipid Profile-smoking	1 day	The lipid profile of the subject group will be evaluated through the use of painless tapes that will be applied to the skin.

Secondary Outcome Measures

Name	Time	Method
Skin Barrier Function- aging	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- acne	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- atopic dermatitis	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.
Skin Barrier Function- smoking	1 day	The skin barrier function will be evaluated for this group through the use of non-invasive handheld devices. These devices provide information about sebum secretion rate, skin water loss, and skin hydration.

Trial Locations

Locations (1)

UC Davis Department of Dermatology; 🇺🇸 Sacramento, California, United States