Olfactogustatory Perception, Eating Behaviour and Inflammation in Crohn's Disease

Completed

• Conditions: Olfactogustatory Perception; Crohn's Disease
• Interventions: Other: triangular test; Biological: blood sampling; Other: Questionnaires

• Registration Number: NCT02859675
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

This study will improve our understanding of the mechanisms underlying anorexia in persons with Crohn's disease flare-ups. The practical spin-off from this research is potentially very important for the management of nutritional disorders associated with the disease by guiding diets towards foods that correspond to patients' preferences and/or to modified tastes. In addition, the results could lead to the identification of sensory markers that herald an inflammatory flare-up of the disease.

Detailed Description

Not available

Study Timeline

• Study Start: 2013-10-07
• Study First Submitted: 2016-07-28
• Study First Submitted QC: 2016-08-04
• Study First Posted: 2016-08-09
• Primary Completion: 2021-05-03
• Study Completion: 2021-05-03
• Status Verified: 2024-02
• Last Update Submitted: 2024-02-21
• Last Update Posted: 2024-02-22

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 62

Inclusion Criteria

• Age between 18 and 60 years,
• Diagnosis of Crohn's disease according to clinical, endoscopic, histological, radiological and biochemical criteria as defined by the European Consensus Conference,
• Men or women who have provided consent and willing to cooperate.

Exclusion Criteria

• Chronic inflammatory intestinal disease (CIID) other than Crohn's disease: haemorrhagic rectocolitis, undetermined colitis, microscopic colitis.
• Intercurrent disease (diabetes and metabolic disease, liver cirrhosis, progressive cancer, acute or chronic infection, Human Immunodeficiency Virus HIV),
• Organ failure (respiratory, heart, or renal failure, neurological disorders),
• Intolerance to gluten,
• Treatments (other than those used for Crohn's disease) able to interfere with food intake,
• Aversion to foods consumed or smelled,
• Poor understanding of cognitive tasks required.
• Crohn's disease complicated by an abscess or infectious complication
• Acute Crohn's disease defined by a CDAI score > 150

For Controls:

Inclusion Criteria:

• Adult person
• Without follow-up for a chronic pathology
• Having given its consent

Exclusion Criteria:

• Protected adult
• Person not affiliated to a social security system
• Pregnant or breastfeeding woman
• Active smoker
• No one who does not speak French
• Taking treatment that interferes with taste or acts on the central nervous system

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Crohn and without anti-TNF treatment	triangular test	tests performed according to patient availability
Control	triangular test	tests performed according to patient availability
Crohn and anti-TNF treatment	blood sampling	Tests at 3 or 4 weeks after the beginning of anti-TNF treatment
Crohn and without anti-TNF treatment	blood sampling	tests performed according to patient availability
Crohn and anti-TNF treatment	triangular test	Tests at 3 or 4 weeks after the beginning of anti-TNF treatment
Crohn and anti-TNF treatment	Questionnaires	Tests at 3 or 4 weeks after the beginning of anti-TNF treatment
Control	blood sampling	tests performed according to patient availability
Control	Questionnaires	tests performed according to patient availability
Crohn and without anti-TNF treatment	Questionnaires	tests performed according to patient availability

Primary Outcome Measures

Name	Time	Method
Modification of sweet taste	through the study completion up to 10 years	the measurement of detection thresholds consists in presenting to the participants in order of increasing concentrations, series of forced-choice triangular tests

Trial Locations

Locations (1)

Centre Hospitalier Universitaire; 🇫🇷 Dijon, France