Taste Physiology in Obese Volunteers Before and After Bariatric Surgery

Not Applicable

Recruiting

• Conditions: Obesity
• Interventions: Dietary Supplement: Quinine; Dietary Supplement: Glucose; Dietary Supplement: Placebo; Dietary Supplement: Monosodium glutamate

• Registration Number: NCT02902198
• Lead Sponsor: University Hospital, Basel, Switzerland

Brief Summary

The objective is to investigate neuro-anatomical correlates of gastrointestinal taste stimulation by means of functional MRI before and after bariatric surgery. Intragastric administration of glucose, monosodium glutamate, chloroquine and placebo is followed by functional brain MRI in obese humans before and 3 months after surgery.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-12
• Study First Submitted: 2016-09-12
• Study First Submitted QC: 2016-09-12
• Study First Posted: 2016-09-15
• Status Verified: 2025-03
• Last Update Submitted: 2025-03-31
• Last Update Posted: 2025-04-03
• Primary Completion: 2026-12
• Study Completion: 2027-12

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 16

Inclusion Criteria

• morbidly obese patients (BMI min 35kg/m2) scheduled for bariatric surgery
• right handed

Exclusion Criteria

• cardiovascular disease
• neurologic/psychiatric disorders

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Arm && Interventions

Group	Intervention	Description
Quinine preoperative	Quinine	Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube
Quinine postoperative	Quinine	Single intragastric instillation of 200ml tap water with 17mg quinine via nasogastric tube
Glucose preoperative	Glucose	Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube
Placebo preoperative	Placebo	Single intragastric instillation of 200ml tap water via nasogastric tube
Glucose postoperative	Glucose	Single intragastric instillation of 200ml tap water with 25g glucose via nasogastric tube
Placebo postoperative	Placebo	Single intragastric instillation of 200ml tap water via nasogastric tube
Monosodium glutamate preoperative	Monosodium glutamate	Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube
Monosodium glutamate postoperative	Monosodium glutamate	Single intragastric instillation of 200ml tap water with 1g monosodium glutamate via nasogastric tube

Primary Outcome Measures

Name	Time	Method
Effect of tastants on cerebral blood flow measured by functional brain MRI	changes from baseline to one hour after treatment

Secondary Outcome Measures

Name	Time	Method
Effect of tastants plasma glucagon-like peptide (GLP-1) concentrations	changes from baseline to one hour after treatment
Effect of tastants plasma ghrelin concentrations	changes from baseline to one hour after treatment

Trial Locations

Locations (1)

University Hopital Basel; 🇨🇭 Basel, Switzerland