Mechanisms and treatment of chronic cough

Not Applicable

Withdrawn

• Conditions: Idiopathic chronic cough; Respiratory - Other respiratory disorders / diseases

• Registration Number: ACTRN12605000300673
• Lead Sponsor: Woolcock Institute of Medical Research

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2005-09-05
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Withdrawn
• Sex: All
• Target Recruitment: 50

Inclusion Criteria

Diagnosed with chronic cough that has been present for over 8 weeks, subjects with chronic cough will fall into two categories: cause of chronic cough is well-defined ie mild asthmatics, gastro-oesophageal reflux sufferers, rhinosinusitis sufferers, etc.; cause of chronic cough is obscure, and previous investigations have failed to identify a cause.

Exclusion Criteria

Upper or lower airway infection in the past four weeks;Pregnancy: female participants of child bearing potential will be tested for pregnancy, by urine pregnancy test, before the capsaicin provocation, and if found to be pregnant will be excluded from the study; Smokers;Uncontrolled major diseases, including psychiatric disorders, heart conditions, high blood pressure or others deemed of significance by the investigator;People with any reported allergic reaction to pepper or ethanol.

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
In the first visit of the study, the history of chronic cough will be elucidated and all investigations already performed by their medical doctors will be recorded. Once all the investigations for common causes of cough were performed and a cause for chronic cough is still obscure, we will book a second visit to perform provocation with capsaicin, to evaluate the possible primary hypersensitivity of the airways.[]

Secondary Outcome Measures

Name	Time	Method
A third visit will be booked to evaluate the response of the airways and cough to dry air by eucapnic voluntary hyperpnea. This provocation has the purpose of evaluating the association between chronic cough and dryness of the airways.[]