Influence of heart rate reduction on heart injury that happens during interventional coronary procedure and stent deployment in patients with coronary disease
- Conditions
- Ischemic heart disease with stable anginaCirculatory System
- Registration Number
- ISRCTN59609019
- Lead Sponsor
- niversity clinical center Maribor
- Brief Summary
2014 Abstract results in https://esc365.escardio.org/Congress/ESC-CONGRESS-2014/Poster-session-1-Strategies-to-prevent-PCI-complications/103007-pretreatment-with-ivabradine-reduces-periprocedural-myocardial-injury-and-infarction-in-stable-ischemic-patients-undergoing-coronary-intervention#abstract Presented at ESC Congress 2014 (added 05/08/2021) 2021 Results article in https://actamedbio.mf.um.si/en/article/Heart+rate+reduction+using+ivabradine+protects+against+periprocedural+myocardial+injury+and+angina+symptoms+in+patients+with+stable+coronary+disease+undergoing+coronary+intervention_1363 (added 05/08/2021)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 78
1. Patients scheduled for elective PCI
2. Suspected or established coronary artery disease
3. Presence of sinus rhythm
4. Resting heart frequency above 70 beats per minute
1. Previous pacemaker implantation
2. Symptoms and signs of heart failure
3. Ejection fraction of left ventricle below 50%
4. Levels of creatinine above upper level of normal (ULN)
5. Already treated with ivabradine
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Periprocedural myocardial injury, measured using cardiac troponin I assay (Siemens Healthcare Diagnostics) from blood samples at admission (before the procedure) and 24 hours after the procedure
- Secondary Outcome Measures
Name Time Method Symptoms of angina, assessed with the number of angina attacks (chest pain) per week, on the day of inclusion and 1 month after the inclusion