The Influence of Heart Rate Reduction Upon Central Arterial Pressure in Younger and Older Healthy Individuals
- Registration Number
- NCT01029223
- Lead Sponsor
- Bayside Health
- Brief Summary
The purpose of this study is to determine the effect of slowing heart rate upon both central and peripheral blood pressures using a medication called Ivabradine which slows heart rate without affecting heart contraction, and to compare the effects of ivabradine to a traditional blood pressure lowering medication called metoprolol (which is a beta-blocker).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- Male
- Target Recruitment
- 42
Inclusion Criteria
- Aged 18 - 25 years OR
- Aged > 60 years
Exclusion Criteria
- Chronic disease
- Unable to give informed consent
- Treated or untreated systemic arterial hypertension (SBP > 160 mmHg and/or DBP > 90 mmHg)
- Resting bradycardia (heart rate < 60 beats/minute)
- Pregnancy or active lactation
Exclusion Criteria
Not provided
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Arm && Interventions
Group Intervention Description placebo placebo - ivabradine ivabradine - metoprolol metoprolol -
- Primary Outcome Measures
Name Time Method central and peripheral arterial and pulse wave velocity baseline, and 4 hours following the administration of placebo, metoprolol or ivabradine.
- Secondary Outcome Measures
Name Time Method Central pulse pressure Baseline measurements of central and peripheral arterial and pulse wave velocity will be made at baseline, and 4 hours following the administration of either placebo, metoprolol or ivabradine.