Significance of arterial lactate levels as a mortality indicator in sepsis patients.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 64
- 试验地点
- 1
- 主要终点
- To determine the association of initial arterial lactate level and thirtyth day outcome in patients with sepsis
研究概览
简要总结
Sepsis is the leading cause of morbidity and mortality and the second commonest cause of death worldwide. Raised blood lactate levels in severe sepsis and septic shock usually indicate impaired oxidative phosphorylation secondary to reduced oxygen availability to the cells (hypoxic hypoxia) and/or tissue hypoperfusion (stagnant hypoxia). Because blood lactate levels can be measured easily and quickly, these have been used as a predictor of tissue hypoperfusion in critically ill patients admitted to the intensive care unit (ICU). Systematic studies on arterial lactate and lactate clearance are lacking in the Indian subpopulation with sepsis. In the present study, we aim to determine association of arterial lactate and lactate clearance and 30th day mortality in patients with sepsis
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Patients diagnosed with sepsis admitted to ICU.
排除标准
- •Patients/legally responsible relatives of patient refusal to participate in study, unable to do sixth hour follow up for lactate levels, initial lactate less than 2 mmol per litre,history of major surgery,polytrauma,HIV,malignancy,pregnancy,patients taking biguanides or salicylates.
结局指标
主要结局
To determine the association of initial arterial lactate level and thirtyth day outcome in patients with sepsis
时间窗: day 1 and day30
次要结局
- to determine the association of arterial lactate clearance and thirtyth day outcome in septic patients
- to compare the association between initial arterial lactate level and lactate clearance with thirtyth day mortality in patients with sepsis(day1 and day30)
研究者
Sowmya M J
Rajarajeswari medical college and hospital