Task-related TRAINing in Huntingtons Disease

Completed

Conditions: Dementias and Neurodegenerative Diseases
Mental and Behavioural Disorders
Dementia in Huntington's disease

Registration Number: ISRCTN94284668

Lead Sponsor: Cardiff University (UK)

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: All

Target Recruitment: 30

Inclusion Criteria

1. Diagnosis of manifest HD, confirmed by genetic testing
2. Self-reported or physician-reported difficulties with walking and/or balance
3. Between ages of 18 and 70 years
4. Capacity to give informed consent
5. Total functional capacity (TFC) of at least 4
6. Stable medication regime for 4 weeks prior to initiation of trial, and be able to maintain a stable regime for the course of trial
7. Enrolled on EHDN Registry/ENROLL study
8. Target Gender: Male & Female
9. Upper Age Limit 70 years
10. Lower Age Limit 18 years

Exclusion Criteria

1. Hhistory of prior neurological condition, such as stroke
2. Unable to understand or communicate in spoken English
3. Moderate to severe arthritis in the hips, knees or ankles, or orthopaedic condition that limits walking ability
4. Cardiac precautions that would prevent subject from completing the intervention or the full battery of outcomes
5. Currently in receipt of active physiotherapy input
6. Are currently involved in any interventional trial or within 2 months of completing an interventional trial
7. Are not enrolled (or interested in enrolling) on the EHDN Registry/ ENROLL study
8. Demonstrate uncontrolled psychiatric symptoms / have active psychosis

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Physical Performance Test measured at 0 weeks (baseline), 8 weeks and 16 weeks

Secondary Outcome Measures

Name	Time	Method
1. 30 second chair stand test measured at 0 weeks (baseline), 8 weeks and 16 weeks<br>2. 30-second chair stand test by the treating therapists measured at once a week<br>3. Depression will be quantified by the Hospital Anxiety and Depression Scale (HADS) at 0 weeks (baseline), 8 weeks and 16 weeks<br>4. Quality of life as measured by the Huntington?s Disease Quality of Life Measure (HD-QOL) measured at 0 weeks (baseline), 8 weeks and 16 weeks<br>5. The Berg Balance Scale measured at 0 weeks (baseline), 8 weeks and 16 weeks<br>6. Timed Up and Go walking speed as measured by 10 m walk measured at 0 weeks (baseline), 8 weeks and 16 weeks