Role of Transcrainal Direct Current Brain Stimulation in Acute and Chronic Post-mastectomy Pain Management
试验速览
- 阶段
- 不适用
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- total morphine comsuption
研究概览
简要总结
the role of transcranial magnetic stimulation over the primary motor cortex area on acute postoperative pain after breast cancer surgery and on the probability of developing chronic neuropathic pain.
详细描述
New analgesic strategies are needed that can be used adjunctively to existing strategies with the potential to reduce reliance on opioid analgesia. Several novel brain stimulation technologies including transcranial direct current stimulation (tDCS) are beginning to demonstrate promise as treatments for a variety of pain conditions. Electricity has no metabolite or other residue, and can be delivered with minimal discomfort and without problems associated with drug-drug interactions.Transcranial direct current stimulation has been studied in patients with various disorders and multiple pain syndromes. There is also evidence that tDCS might be useful in postsurgical pain reduction.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 30 Years 至 60 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •ASA I-II, scheduled for unilateral modified radical mastectomy with axillary dissection for breast cancer
排除标准
- •patients with intracranial metallic devices or with pacemakers or any other device.
- •patients with Neurological or psychiatric disorders,
- •patients taking major centrally acting drugs (antiepileptics or antidepressants), -opioid dependence,
- •substance abuse,
- •severe cardiopulmonary, renal, hepatic diseases, and
- •those with extensive myocardial ischemia or unstable angina.
结局指标
主要结局
total morphine comsuption
时间窗: 48 hours
the total dose of morphine used as analgesic expressed in mg
次要结局
- Douleur Neuropathique 4 questions DN4(1month, 3month, 6 month)
- Visual analogue scale(baseline,at 2,4,6, 12, 24,36,48 hours)
研究者
Shereen Mamdouh
Lectruer of anesthesia, ICU and pain manegement
Assiut University