Retrospective Descriptive Study on Retroplacental Hematomas in Finistère
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Histological findings in placentas n°2
研究概览
简要总结
Cases with placental abruption will be identified by interrogation of two databases of Brest University Hospital between January 2013 and December 2018. First trimester PAPPA and bhCG levels will be recorded. PlGF levels will be measured in women with an available first trimester serum sample. Histological findings in placentas, course of pregnancies, maternal and fetal characteristics will described and compared between cases with and without placental chronic inflammation.
详细描述
Identification of cases:
Placental abruption cases will be identified by interrogation of two databases of Brest University Hospital between January 2013 and December 2018.
The women diagnosed with placental abruption will be first identified by interrogation of the Medical Registry Department (MRD) of Brest University Hospital and of five other maternities of our county between January 2013 and December 2018, using the keyword "placental abruption".
Simultaneously, placental abruption cases will be identified from the Pathology department files of Brest University Hospital using a computerized database (ADICAP system).
Cases of placental abruption included in the study will be clinically defined and will not be only diagnosed by histological examination. All cases will be reviewed by an experienced obstetrician in order to confirm the diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Pregnant women
- •who had a placental abruption (clinically defined)
- •with an available placental histological examination
- •in one of 5 maternities of our county (Finistère, France)
- •between January 2013 and December 2018.
排除标准
- •Medical termination of pregnancy
- •marginal abruption
- •placenta previa
- •cases without histological examination of the placenta
- •histological cases without compatible clinical signs
- •cases from an unselected maternity.
结局指标
主要结局
Histological findings in placentas n°2
时间窗: through study completion, an average of one year
presence of an histologic placental abruption
Histological findings in placentas n°11
时间窗: through study completion, an average of one year
presence of acute inflammation such as acute chorioamniotitis or funiculitis
Histological findings in placentas n°9
时间窗: through study completion, an average of one year
presence of excessive fibrin deposition
Histological findings in placentas n°8
时间窗: through study completion, an average of one year
presence of chorangiosis or erythroblastosis
Histological findings in placentas n°1
时间窗: through study completion, an average of one year
placenta weight
Histological findings in placentas n°5
时间窗: through study completion, an average of one year
presence of thrombi in the chorionic plate or intervillous thrombi
Histological findings in placentas n°4
时间窗: through study completion, an average of one year
presence of an abnormal umbilical cord
Histological findings in placentas n°3
时间窗: through study completion, an average of one year
presence of an abnormal placental set-up
Histological findings in placentas n°6
时间窗: through study completion, an average of one year
presence of maternal vascular malperfusion lesions such as macroscopic or microscopic infarcts, decidual arteriopathy or abnormal villous maturation
Histological findings in placentas n°7
时间窗: through study completion, an average of one year
presence of fetal vascular malperfusion signs such as obliterative fetal vasculopathy or avascular villi
Histological findings in placentas n°10
时间窗: through study completion, an average of one year
presence of chronic inflammation such as villitis or chronic intervillositis of unknown etiology, chronic chorioamniotitis or chronic deciduitis
次要结局
- Maternal first trimester biological markers n°3(through study completion, an average of one year)
- Course of the pregnancies n°1(through study completion, an average of one year)
- Maternal first trimester biological markers n°1(through study completion, an average of one year)
- Course of the pregnancies n°2(through study completion, an average of one year)
- maternal characteristics n°2(through study completion, an average of one year)
- maternal characteristics n°9(through study completion, an average of one year)
- fetal characteristics n°1(through study completion, an average of one year)
- fetal characteristics n°2(through study completion, an average of one year)
- Course of the pregnancies n°4(through study completion, an average of one year)
- Course of the pregnancies n°6(through study completion, an average of one year)
- maternal characteristics n°3(through study completion, an average of one year)
- maternal characteristics n°4(through study completion, an average of one year)
- maternal characteristics n°11(through study completion, an average of one year)
- Maternal first trimester biological markers n°2(through study completion, an average of one year)
- Course of the pregnancies n°5(through study completion, an average of one year)
- Course of the pregnancies n°9(through study completion, an average of one year)
- maternal characteristics n°6(through study completion, an average of one year)
- maternal characteristics n°7(through study completion, an average of one year)
- maternal characteristics n°8(through study completion, an average of one year)
- maternal characteristics n°1(through study completion, an average of one year)
- maternal characteristics n°5(through study completion, an average of one year)
- maternal characteristics n°10(through study completion, an average of one year)
- Course of the pregnancies n°3(through study completion, an average of one year)
- Course of the pregnancies n°7(through study completion, an average of one year)
- Course of the pregnancies n°8(through study completion, an average of one year)
- Course of the pregnancies n°10(through study completion, an average of one year)
- Course of the pregnancies n°11(through study completion, an average of one year)