Postoperative cognitive dysfunction in elderly cancer patients

Completed

Conditions: cognitive dysfunction
memory and attention
10069888
10017998

Registration Number: NL-OMON34981

Lead Sponsor: niversitair Medisch Centrum Groningen

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 150

Inclusion Criteria

Patients over 65 years of age admitted to the Department of Surgery of the University Center Groningen for the surgical or combined cancer treatment (surgery / radiation /chemotherapy / hormonal therapy) of a solid tumor will be included in this study. This will include patients undergoing surgery for a malignancy of the breast, thyroid, soft tissue, hepatobilliairy tract, colorectal tumors, and skin tumors• surgery is scheduled more than 24 hours after inclusion in the study as we feel this is the time necessary to obtain test results and plan the intraoperative recording of data
• surgery under general, local or regional anesthesia.
• written informed consent given according to local regulations

Exclusion Criteria

• any psychological, familial, sociological or geographical condition potentially hampering compliance with the study protocol and follow-up schedule.;• patient unable to comply with the outcome questionnaires

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The incidence of POCD defined by a postoperative change in cognitive function<br /><br>measured by the Ruff Figural Fluency (RFFT) score and Trailmaking test (TMT)<br /><br>score in comparison to the preoperatieve score. Secondary outcome measures are</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>memory (measured by the 15 words test) and daily functioning and quality of<br /><br>life measured by the instruments in the minimale dataset (MDS). These tests<br /><br>will be performed preoperatively and at discharge (or a maximum of 2 weeks<br /><br>postoperatively) and 3 months postoperatively.</p><br>