Investigation of the Relationship Between Uterine Artery Doppler Diastolic Notching and Serum Apelin-13 and Apelin-36 Concentrations Between the 11th and 14th Weeks of Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 88
- 试验地点
- 1
- 主要终点
- Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
研究概览
简要总结
This study was conducted to investigate the relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and 36 concentrations between 11 and 14 weeks of gestation.
详细描述
Apelin-13 and apelin-36, which provide vasodilatation through a nitric oxide-dependent mechanism, also play a role in trophoblasts' survival, proliferation, and migration.
Based on this, we aimed to investigate serum apelin-13 and apelin-36 concentrations in pregnant women with and without diastolic notch on uterine artery Doppler between the 11th and 14th weeks of pregnancy.
We hypothesized that apelin-13 and apelin-36 might be associated with the formation of diastolic notch in uterine artery Doppler and serum apelin-13 and apelin-36 concentrations would be lower in the group with a notch in the uterine artery Doppler than in the group without a notch.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 39 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Nonsmokers,
- •Singleton pregnancies between 11 and 14 weeks of gestation
- •Pregnant women who did not conceive with assisted reproductive methods
排除标准
- •Pregnant women who conceived with assisted reproductive techniques
- •Pregnant women with multiple pregnancies
- •Pregnant women who started with multiples and continued with singletons
- •Pregnant women with any pregestational disease, thrombophilia
- •Pregnant women with any congenital uterine anomaly
- •Pregnant women with a history of recurrent pregnancy loss
- •Pregnant women using aspirin or heparin
结局指标
主要结局
Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
时间窗: through study completion, an average of 1 year
Relationship between diastolic notching on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
时间窗: through study completion, an average of 1 year
Relationship between high pulsatility index on uterine artery Doppler and serum apelin-13 and apelin-36 concentrations.
次要结局
未报告次要终点
研究者
ibrahim kale
associate professor
Umraniye Education and Research Hospital