Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases

Active, not recruiting

• Conditions: Polyps; Cardiovascular Diseases

• Registration Number: NCT03708952
• Lead Sponsor: Zhejiang University

Brief Summary

The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear. This study is conducted in Jinhua, a city with a high prevalence of colorectal cancer in China, to assess the relationship between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases.

Detailed Description

Investigations of lifestyle and dietary factors in relation to precursor lesions of colorectal cancer and cardiometabolic diseases are limited in China. The investigators aim to collect the basic characteristics of participants at baseline, including sex, age, smoking, exercise, marriage, education level, dietary factors and so on, to assess the associations between lifestyle and dietary factors with precursor lesions of colorectal cancer and cardiometabolic diseases. This large cohort - the Lanxi Pre-colorectal Cancer Cohort (LP3C) also included several subcohorts consisting of patients with CVD, diabetes, hypertension, metabolic syndrome, obese/overweight or fatty liver disease. Results from this study will be valuable for colorectal cancer and cardiometabolic disease prevention in China.

Study Timeline

• Study Start: 2018-05-01
• Study First Submitted: 2018-10-14
• Study First Submitted QC: 2018-10-14
• Study First Posted: 2018-10-17
• Status Verified: 2024-01
• Last Update Submitted: 2024-01-07
• Last Update Posted: 2024-01-10
• Primary Completion: 2024-12-01
• Study Completion: 2028-05-01

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 25000

Inclusion Criteria

• Subject aged ≥45 and ≤74 years old
• Subject has complete data on diet and follow-up time

Exclusion Criteria

• Colorectal cancer
• Severe intestines problems

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Numbers of participants with polyps	From entry into the study (baseline:2018-2022) until 2028	All polyps

Secondary Outcome Measures

Name	Time	Method
Numbers of participants with different subtypes of polyps	From entry into the study (baseline:2018-2022) until 2028	Subtypes of polyps, including serrated polyps, hyperplastic polyps, sessile serrated polyps/adenoma
Numbers of participants with cardiometabolic diseases	From entry into the study (baseline:2018-2022) until 2028	Cardiometabolic diseases including cardiovascular disease, diabetes, and hypertension

Trial Locations

Locations (2)

Lanxi Red Cross Hospital; 🇨🇳 Lanxi, Zhejiang, China

Lanxi Hospital of Traditional Chinese Medicine; 🇨🇳 Jinhua, Zhejiang, China