Left Ventricular Function After Primary Percutaneous Coronary Intervention: Role of Speckle Echocardiography

• Conditions: Myocardial Infarction; Echocardiography 2D; Left Ventricular Dysfunction
• Interventions: Diagnostic Test: Speckle tracking echocardiography

• Registration Number: NCT04103008
• Lead Sponsor: Assiut University

Brief Summary

Recovery of the left ventricular function is variable from one patient to another, thus assessment of cardiac function by measuring left ventricular ejection fraction using echocardiography is the most common in the daily clinical practice. However, this technique has limitation related with its intra- and interobserver variability. A recent technique, 2D speckle tracking for assessing global longitudinal strain, has been introduced to reduce the variability and potentially has a higher accuracy. Speckle tracking is a method which uses two dimensions recording for measuring quantity of movement of myocardium in several segments.

Speckle-tracking echocardiography is a current noninvasive ultrasound imaging technique that allows for an objective and quantitative evaluation of global and regional myocardial function independently from the angle of insonation and from cardiac translational movements,

Detailed Description

Authors using 2D speckle tracking found that subclinical LV systolic dysfunction is common in patients with isolated severe mitral stenosis (MS) and is determined primarily by the hemodynamic variables of MS severity and reduced LV filling. BMV results in rapid recovery of LV systolic function in these patients through improvement in LV diastolic loading. These findings suggest that LV contractile properties in MS are modulated predominantly by LV diastolic filling rather than myocardial structural abnormality.

Study Timeline

• Status Verified: 2019-09
• Study First Submitted: 2019-09-21
• Study First Submitted QC: 2019-09-23
• Last Update Submitted: 2019-09-23
• Study First Posted: 2019-09-25
• Last Update Posted: 2019-09-25
• Study Start: 2019-11-01
• Primary Completion: 2020-09-01
• Study Completion: 2020-12-01

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients with acute myocardial infarction eligible for PCI seen on admission and after 40 days

Exclusion Criteria

• cardiomyopathy
• cancer
• on cytostatic treatment.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Group A	Speckle tracking echocardiography	single coronary artery lesion
Group B	Speckle tracking echocardiography	multiple coronary artery lesions

Primary Outcome Measures

Name	Time	Method
Assessing change of left ventricular function	baseline and after 40 days of PCI	measure ejection fraction

Secondary Outcome Measures

Name	Time	Method
Major adverse cardiovascular events	40 days	non fatal myocardial infarction, non fatal stroke, CV death

Trial Locations

Locations (1)

Assiut University Hospitals; 🇪🇬 Assiut, Egypt