Trial of Vitamins in HIV Progression and Transmission
Overview
- Phase
- Phase 3
- Intervention
- Not specified
- Conditions
- HIV Infections
- Sponsor
- Harvard School of Public Health (HSPH)
- Enrollment
- 1085
- Locations
- 1
- Primary Endpoint
- To examine the effect of multivitamin and/or Vitamin A supplements on the risk of perinatal transmission of HIV and rate of HIV disease progression
- Status
- Completed
- Last Updated
- 15 years ago
Overview
Brief Summary
This study tested the hypothesis that multivitamin supplementation given to HIV+ pregnant women in Tanzania would slow disease progression and enhance their overall health.
Detailed Description
In this study, we sought to examine whether the administration of multivitamins excluding vitamin A, multivitamins including vitamin A, or vitamin A alone would reduce the risk of perinatal transmission of HIV and slow the rate of disease progression in a group of pregnant HIV infected women. We also examined the efficacy of the supplements on pregnancy outcomes, and risks of maternal and child morbidity and wasting.
Investigators
Eligibility Criteria
Inclusion Criteria
- •HIV-infected women presenting to antenatal care between 12 and 27 weeks of gestation:
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
To examine the effect of multivitamin and/or Vitamin A supplements on the risk of perinatal transmission of HIV and rate of HIV disease progression
Time Frame: until the end of follow-up in August, 2003
Secondary Outcomes
- To examine the effect of multivitamin and/or Vitamin A supplements on child and maternal morbidity, child growth and child mortality(until the end of follow-up in August 2003)