Bowel surgery influences body's water, electrolyte and sugar control

Not Applicable

Completed

• Conditions: Metabolic disturbances following colectomy; Surgery

• Registration Number: ISRCTN76735966
• Lead Sponsor: orth West London Hospitals NHS Trust (UK)

Brief Summary

2015 Abstract results in http://dx.doi.org/10.1136/gutjnl-2015-309861.1148 (added 29/09/2021) 2016 Thesis results in https://doi.org/10.25560/72428 (added 29/09/2021)

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2013-03-21
• Study Completion: 2014-12-31
• Last Update Posted: 11 October 2021

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Participants who have undergone IRA or RPC or colectomy with ileostomy
2. Surgery >1 year previously, or preoperative patients (part 3)
3. Absence of small bowel disease, Crohn's, Coeliac disease etc
4. No recent use of steroid medication (< 1 year)
5. 18 < BMI < 30 kg/m2
6. Minimal small bowel resection (<10 cm)
7. Aged 14-70 years

Exclusion Criteria

1. Patients with diabetes
2. Patients who are unwilling to consent
3. Patients who are regularly taking the electrolyte mix
4. Patients with any known adrenal gland disorder

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To determine how prevalent sodium depletion and hyperaldosteronism are in well adapted patients following ileorectal anastomosis (IRA) or restorative proctocolectomy (RPC) or colectomy with ileostomy.

Secondary Outcome Measures

Name	Time	Method
<br> 1. To determine if sodium depletion in well adapted patients following IRA or RPC or colectomy with ileostomy is associated with and causative of abnormal glucose tolerance.<br> 2. To ascertain if these metabolic changes can be reversed with a simple rehydration therapy which could be easily incorporated into patient aftercare.<br> 3. To ascertain if these metabolic changes can be prevented from developing post-operatively with a simple rehydration therapy which could be easily incorporated<br> 4. Differences in health-related quality of life scores as assessed using SF-36 and FACIT- F questionnaires<br>